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Antibiotics

Terms in this set (4)

Name 5 classes of hydrophilic agents
Beta-lactams
Aminoglycosides
Glycopeptides
Daptomycin
Colistimethate
Name 6 classes of lipophilic agents
Fluoroquinolones
Macrolides
Rifampin
LInezolid
Tetracyclines
Chloramphenicol
5 characteristics of hydrophilic agents
1. Small Vd --> Poor tissue penetration
2. Renal elimination --> Nephrotoxic
3. Does not achieve intracellular conc --> no atypical coverage
4. Incr clearance and/or disribution in sepsis --> Consider LD and aggressive dosing in sepsis
5. Poor-moderate bioavailability --> PO to IV ratio < 1
5 characteristics of lipophilic agents
1) Large Vd --> excellent tissue penetration
2) Hepatic metabolism --> Hepatotoxicity and DDI
3) Achieves intracellular conc --> Atypical coverage
4) Clearance/distribution has minimal change in sepsis --> Dose adj generally not needed in sepsis
5) Excellent bioavailability --> PO to IV ratio often 1:1
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