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adrenergic agonists

Terms in this set (30)

Phenylephrine
Oxymetazoline
Tetrahydrozoline
Methoxamine
DIRECT ACTING a1 agonist
Clonidine
Dexmedetomidine
Guanabenz
Guanfacine
methyldopa
direct acting a2 agonist
Isoproterenol
Dobutamine
Metaproterenol
Terbutaline
Albuterol
Salmeterol
Pirbuterol
Formoterol
direct acting b agonist
Amphetamine
Cocaine
Tyramine
indirect acting agonists
Ephedrine
Pseudoephedrine
mixed acting agonists
Dopamine
Epinephrine
Norepinephrine
endogenous agonists
pt comes in complaining of severe palpitations, chest pain, headache after an asthma attack. the patient states they took their puffer which helped their breathing but are now complaining the above symptoms. the pt states the pharmacist was concerned about the prescription for the puffer and cautioned the patient about its use. what drug? why such severe side effects?
isoproterenol
non selective beta agonist
where can norepi NOT have an effect
CNS because cant cross BBB
for dopamine low doses effect? high doses effect?
b1
a1
2 reasons dobutamine used to treat CHF
B1 agonist
does not increase cardiac MVO2
oxymetazoline used for? adverse effects (5)?
eye or nose vasoconstrictor

Adverse effects:
Nervousness
Headaches
Insomnia
Burning of nasal mucosa
Rebound congestion
phenylephrine is common in what type of drug?
decongestant
what receptor does phenylephrine favour?
alpha 1
a pt has a hypothetical genetic disease where they dont produce COMT. how will this effect phenylephrine metabolism?
it won't as phenylephrine is not a substrate for COMT
a patient comes in with a very rapid heart rate. it is determined they are in SVT. what alpha agonist may be appropriate to treat this patient?
methoxamine
clonidine similar to which 2 drugs?
guanabenz and guanfacine
therapeutic uses and mechanism of clonidine?
a2 agonist &

Lower BP in essential hypertension- CNS action
Aids in withdrawal symptoms of alcohol, opiates and benzodiaepines
Sometimes used for restless leg syndrome and rosacea
metaproterenol is a catecholamine. true or false?
false
main target and function of metaproterenol?
B2 agonist
bronchodilation
a pt is having an asthma attack during a major track competition. as the race doctor you quickly attempt administer a drug which the pt initially refuses concerned about possibly being disqualified. you state that while this drug is for emergencies and while not approved for off label use in sports it is not illegal. what drug is it?
albuterol
also may use:
pirbuterol, terbutaline
high doses of albuterol may cause what
hypokalemia
salmeterol & formoterol are what types of drugs?
long acting B2 agonists for bronchodilation
what two adrenergic agonists are least selective
epinepherine
ephedrine
what is MOA of amphetamine?
block norepi reuptake and increase norepi release
where are amphetamines effects therapeutic?
CNS
what does tyramine do and where is it found?
it increases norepi release. it is found in ripe cheese, wine, beer, smoked/cured meats and fish
who should avoid tyramine?
persons on MAOI
MOA for mixed agonists
increase norepi release and direct receptor agonist
2 examples of mixed agonists
ephedrine
pseudoephedrine
why do the mixed agonists have long duration of action?
not substrate for COMT or MAO.
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