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Autoantibodies

Terms in this set (29)

Myasthenia gravis
Anti-ACh receptor (blocks receptor)
Goodpasture syndrome
Anti-glomerular basement membrane
Antiphospholipid syndrome
1. Anti-beta2 glycoprotein: increased thrombosis (arterial or venous) or spontaneous abortion from placental clots, strokes, hepatic vein clots
2. lupus anticoagulant = hyper-coagulation!
3. anticardiolipin

- associated with SLE bc both have False positive VLDR (anticardiolipin)
- treated with heparin
lupus
1. Anticardiolipin
2. Lupus anticoagulant
3. SPECIFIC: Anti-smith and anti-dsDNA abs
4. Anti nuclear bodies
5. Anti-histones: Rx-induced
Limited scleroderma (CREST syndrome)
Anticentromere
Diffuse Scleroderma
anti-Scl-70 antibody (anti-DNA topoisomerase)
Pemphigus vulgaris
Anti-desmoglein
Type 1 DM
Anti-glutamic acid decarboxylase (GAD)
Anti-islet cell cytoplasmic antibodies
Bullous pemphigoid
Anti-hemidesmosome
Polymyositis
Dermatomyositis
Antisynthetase (anti-Jo-1)
Anti-SRP
Anti-helicase (anti-Mi-2)
Sjogren's syndrome
Anti-SS-A (Anti-Ro)
Anti-SS-B (Anti-La)
Hashimoto thyroiditis
Antimicrosomal
Antithyroglobulin
Anti-thyroid peroxidase (TPO)
Primary biliary cirrhosis
Antimitochondrial
Pernicious anemia
Antiparietal cell
Anti-intrinsic factor
Primary membranous nephropathy
Antiphospholipase A2 receptor
85% of membranous nephropathy
Scleroderma (diffuse)
Anti-Scl-70 (anti-DNA topoisomerase I)
Autoimmune hepatitis type 1
Anti-smooth muscle
Sjogren syndrome
Anti-SSA (Ro), anti-SSB (La)
Graves disease
Anti-TSH receptor (activates it)
Lambert-Eaton myasthenic syndrome
Anti-presynaptic voltage-gated calcium channel
Celiac disease
IgA anti-endomysial
IgA anti-tissue transglutaminase
VASCULITIS:
- Microscopic polyangiitis
- Eosinophilic granulomatosis with polyangiitis
- Ulcerative colitis
MPO-ANCA / p-ANCA
Granulomatosis with polyangiitis
PR3-ANCA / c-ANCA
Rheumatoid arthritis
Rheumatoid factor (IgM against IgG Fc region)
Anti-CCP (more specific)
Often associated with SLE (non-specific)
Antinuclear (ANA)
SLE
Anti-dsDNA
Anti-smith
Drug-induced lupus
Anti-histone
Mixed connective tissue disease
Anti-U1 RNP (ribonucleoprotein)
Wegener's granulomatosis
c-ANCA
- vasculitis: necrotizing granulomas of lung & necrotizing glomerulonephritis
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