Upgrade to remove ads
Terms in this set (149)
Major manifestation of familial chylomicronemia
Major manifestation of familial hypercholesterolemia
Premature coronary artery disease
Major manifestation of familial dysbetalipoproteinemia
Premature coronary artery disease
Most common cause of mitral stenosis
Hamartomatous polyps in GI tract
Broad fasciles of rounded fibroblasts with abundant cytoplasm
Surrounded by collagenous matrix
Lipoma vs liposarcoma
Liposarcoma shows pleomorphism (scalloping of nuclear membrane)
Chronic alcoholism can damage what part of the brain to cause gait ataxia, truncal instability, intention tremor, Parksinonian tremor
Likely due to thiamine deficiency
What type of DI does lithium cause
Coronary artery status in hypertrophic cardiomyopathy?
Causes of wide split S2
Right bunlde branch block
Pulmonary arterial hypertension
Lengthinging of RV ejection time
CD40 Ligand deficiency
Only IgM is procued
Common variable immunodeficiency
Low IgG, E, M, A
Best ROC curve
Largest area under the curve
Neoplasms associated with Lynch syndrome
Protein involved in ataxia telangiectasia
Nonhomologous end joining repair mechanism
Side effects of calcineurin inhibitors
Dose and duration dependent rise in BUN and creatinine
Also renal arteriolar vasoconstriction
Long term use leads to obliterative vasculopathy
Anti-emetic that is contraindicated in parkinsons disease?
can triggger extrapyramidal effects
Clinical features of alkaptonuria
Darkening of urine
Blue black discoloration of cartilage and skin
Ischemia causes what electrolyte to increase extracellularly?
3 mechanisms that stimulate juxtaglomerular cells
Decrased NaCl sensed by macula densa
Decreased pressure in afferent arteriole
Foam stability index is used to evaluate...
Female athlete triad
Why is heparin unable to cross placenta, while warfarin can?
Heparin is charged and water soluble
Warfarin is lipophilic
CMV retinitis appearance
Bilateral retinal hemorrhages
Cotton wool exudates on opthalmoscopic examination
Encouraging internal motivators for change
Peaked T waves
Which wave would disappear in afib in a jugular venous pulse tracing?
Tetralogy of fallot murmur
Systolic ejection murmur
Systolic thrill at left sternal border
Pineal gland function
Modulate circadian rhythm
UIpward gaze palsy
Absent pupillary light reflex
Can be caused by pineal gland compressing superior colliculus
How can pineal gland cause parinaud syndrome?
Mass effect on DORSAL MIDBRAIN in superior colliculus region
Where are GI stem cells located
Cryptos of Lieberkuhn
What cells are in the regenerative nodules of a cirrhotic liver?
Stellate cell function
In the hepatic perisinusoidal space
Store Vit A
Macrolides and clindamycin bind to the same site on...
23S rRNA on 50S ribosomal subunit
Painless, compressible mass that transilluminates
Typically on head or neck
Cystic hygromas are associated with what genetic abnormality?
Recent outdoor activitiy
Exposed skin with streaky, erythematous lesions
Type IV hypersenstiivty
Poison oak/ivy (toxicodendron)
What causes late onset lactose intolerance?
Downregulation of lactase
Which tissue is most radiation sensitive?
Kluver Bucy syndrome due to damage to..
PArticularly the amygdala
Lateral to lentiform nucleus
Subjective emotional experience, pain, etc
Increased in drug abusers to tirgger cravings
Red flags for low back pain
Hx of cancer
Nighttime pain interering with sleep
No response to previous therapy
First line tx for low back pain with no red flags
NSAID or acetaminophen
Mechanism of tardive dyskinesia
Prolonged exposure to dopamine blocking agents causing upregulation and supersensitivty to dopamine receptors
Dopamine beta hydroxylase makes
Hemodynamic changes in pulmonary embolism
Elevated central venous pressure (impaired forward pumping)
Elevated systemic vascular resistance (attmempt to maintain tissue perfusion pressure)
Reduced cardiac output
Which lung volumes INCREASE in COPD?
Cells pile up on a petri dish
What is the main concern of oral polio vacine?
Contains attenuated live virus
Can revert to virulent form and cause vaccine associated paralytic poliomyelitis
How can a woman express an X-linked recessive disorder?
How do most dsDNA viruses replicate
Get into nucleus
DNA depdnent DNA polyermase replicate genome
Then transcribed with DNA depdentn RNA polymerase
Eosinophilic cytoplasmic inclusions in hippocampal neurons
Painful pharyngeal muscular spasms
Glomerular capillary filtration coefficient is based on
Surface area of glomerular capillaries
What two things should women of childbearing age do when using retinoids?
Abstain from alcohol use (can lengthen half life)
Not conceive for 3 years after stopping the drug
Vitamin D analog
Used for psoriasis
How do beta lactams improve aminoglycoside efficacy?
Compromise the bacterial cell wall
Allow aminoglycoside to penetrate
Intestinal lipase inhibitor
Inhibits pancreatic alpha amylase and alpha glucosidase enzymes
Blocks digesting of complex carbohydrates
Spike and dome nephropathy
Which veins drain below the dentate line?
Middle and inferior rectal veins
Drain via internal iliac veins
Treatment for xerosis
Moisturizing skin with creams or ointments
Applied after bathing
Ithcy rash and dry cracked skin
PFK-2/F-2,6 BPase bifunctional enzyme
What does insulin do?
Increase Fructose 2,6 bisphosphate
Which then promotes PFK-1
Nonpolar amino acids
First nerve damaged in cavernous sinus thrombosis
What can happen in testicles in mumps infection?
Results in Leydig cell atrophy
Androgen used to suppress FSH and LH release
How are entamoeba cysts transfered?
Oral fecal contact
What do you see when staining C trachomatis?
Does not gram stain well
Shows neutrophils, no organisms
Tx for C trachomatis?
Probenecid action in kidney
Inhibits organic anion transporters
Why give probenecid with penicillin?
Prevents secretion of penicillin, increasing serum penicillin
Where can tetracyclines deposit in fetus?
deposited in bone and tooth enamel
Cause tooth discoloration and retarded bone formation
Lack of secondary sex characteristics
17a hydroxylase deficiency
Why does giving cortisol relieve hypertension in 17a hydroxylase deficiency?
Lowers ACTH stimulation of upstream precursors
Increased intrathoracic pressure during coughing episode
Decrease venous return to the heart
Transient decrease in CO and cerebral perfusion
Waxing and waning lymphadenopathy
Histology of follicular lymphoma
Tightly packed lymphoid follicles
Small lymphocytes with cleaved nuclei and large non-cleaved lymphocytes
Neutrophils accumulate in crypt lumina
Amenhorrhea in women age <40
Primary ovarian insufficiency
Agglutination inhibition reaction
What is a poistive result?
ABSENCE of agglutination
The presence of the antigen prevents agglutination
Why put paclitaxel on stent?
Prevent intimal hyperplasia
Where does influenza virus replicate?
Other RNA virus would be retroviruses
7 transmembrane hydrophobic a-helices receptor
G protein coupled receptor
Transmit through GTP-binding G proteins
Accumulation of carbamoyl phosphate
Ornithin transcarbamoylase deficiency
Defective proline hydroxylation leads to...
failure of triple helix formation and stabilzation
What nerve is impinged?
Excessive preoccupation with one more somatic complaints, resulting in functional impairment and high health care utilization
Somatic symptom disorder
Why are postmenopausal women at risk for osteoporsosis?
Ovarian endocrine hypofunction
Recent retrograde and anterograde amnesia
Confusion and confabulation
LH, ACTH, Renin levels in 17a hydroxylase deficiency
Increase ACTH and LH
How do medium length FA dehydrogenase deficiency pt present?
Neurologic and hepatic dysfunction
Early signs of hypokalemia
Muscle weakness,cramps, myalgias, fatigue
Psoas abscess can spread to the...
Risk of developing herpes zoster (shingles)
What does angiontensin 2 do to renin?
Inhibits renin release
Adult acute respiratory distress syndrome
Alveoli fill with proteinaceous material and cell debris
Infeective gas exchange
Right to left shunting leads to hypoxemia
Widespread inflammation causes redistribution of blood away from wel-ventilated alveoli
Leads to increased alveolar dead space
Severe pneumonia with normal ABG
Develops hypercapnia, respiratory acidosis
Where does copper deposit in Wilson's disease?
Descemet's membrane in cornea
Wilson's disease presentation
'Neuro: dystonia, tremor, dysarthria, dysphagia
Well demarcated, nontender, firm, spherical, mobile breast nodule
Dysplastic nevi can potentially evolve into
Dysplastic nevus syndrome is associated with a melanoma susceptibility locus ...
Inhibits CDK4 normally
Fibroblasts in a cartwheel or storiform pattern
Chromosomes 17 and 22
Malignant fibrous histiocytoma
Proliferation of highly atypical and pleomorphic fibroblasts, histiocyte like cells, bizarre giant cells
Aortic dissection on chest x ray
Widening of mediatsinum
Abnormal aortic contour
Risks: uncontrolled HTN
Cardiovascular changes in exercise
Vasodilation of exercising muscles
Increased end disatolic volume and HR
Decreased end systolic volume (heart empties out more) and systemic vascular resistance
First step in pyrmidine synthesis
Glutamine, CO2, 2 ATP form carbamoyl phosphate via carbamoyl phosphate synthetase II
Hydrogen peroxide degradation
What effect can alcohol have on the heart?
Particlarly in pt with mutations in alcohol dehydrogenase or DD isoform of ACE
Dilated cardiomyopathy characterstics
Increased ventricular volumes
Normal thickness of ventricular walls
What drug works on fungal cell WALL?
Where does amphotericin B work?
Binds ergosterol, creating pores in fungal cell MEMBRANES
Type IV collagen
Linear IgG deposits in GBM
Form of RPGN
Hydatidiform moles are due to proliferation of...
What marker distinguishes complete and partial moles?
Complete mole stains negative for p57
p57= paternally imprinted but maternally expressed gene
Most common cause of primary hyperparathyroidism
How do retinoids treat acne?
Decrease sebum production
Increase cellular turnover and shedding of cells
Open blocked pores
What goes through esophageal hiatus?
Anterior and posterior trunks of the vagus nerve
What goes through aortic hiatus?
How do dihydropyridines affect cardiac work?
Decrease afterload by causing arteriolar vasodilation at arteriolar smooth muscle
Which organs is glucokinase found?
pancreatic beta cells
Maturiy onset diabetes of the young is due to deficiency in...
Raises the glucose threshold required for insulin release
Von Gierke presentation
Severe fasting hypoglycemia
Hepatomegaly and renal enlargement
Why should Von Gierke pt avoid fructose and galactose?
Cannot convert to free glucose
Enzyme deficiency in Pompe disease
Diffuse muscular weakness
Small firm nonfunctional testes
Increased long bone growth
Lab findings in DIC
Prolonged PT and PTT
Increased fibrin degradation products
Acute lumbosacral radiculopathy is most commonly due to
Vertebral disc herniation
How can you differentiate Salmonella from Shigella?
Salmonella produces hydrogen sulfide
Turns black on TIS agar
Loss of horizontal gaze
Rapidly evolving coma
Most common sites for hypertension associated intracerebral hemorrhage
Thalamus and putamen
thalamic intracerebral hemorrhage
Contralateral sensory loss
Temporary homonymous hemianopia
unilateral abducent nerve palsy
Pupil asymmetry and nonreactivity
Disruption of the blood brain barrier
What type of edema?
Increased permeability nad plasma filtration
Increase in intracellular fluid within neurons, glia, endothelial cells
After cell injury impairs Na/K ATPase
Post ischemic insult
What triggers reactive arthritis?
Urogenital and GI infections
First location of action of C tetani
THIS SET IS OFTEN IN FOLDERS WITH...
Buzzword City. Population: YoU(world)
Buzzword city part 2: the sister city
UWSA 1 buzzword city
YOU MIGHT ALSO LIKE...
USMLEWORLD buzzwords - step 1
FTM Exam 2 Clinical
Pathophysiology Kaplan Review
OTHER SETS BY THIS CREATOR
Level 3- Buzzworld
Buzzword metropolis: somehow I manage
PAS II Final - Biostatistics (SL)
All of the Pharm: LA, GA, AED, SH, APD
OTHER QUIZLET SETS
Sexual Dimorphism of the Brain
Pharmacology 2 - Topic 14 - Antineoplastic drugs:…
205 - Nervous system tumours
13. Inheritance I - Mendelian