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Terms in this set (14)
What is C-reactive protein?
Acute phase protein
Released in inflammation & tissue damage
Disappears when inflammation subsides
Lacks disease specificity
Elevated in many disorder
What disorders have elevated levels of C-reactive protein?
Bacterial and viral infections
What are the characteristics of C-reactive protein?
Appears rapidly after acute tissue injury
4 - 6 hours
Concentration may rise to 1000X normal
Reference range: <0.5 mg/dL
Destroyed at 70EC for 30 minutes
Synthesized by liver
What is the role of C-reactive protein in opsonization?
Binds (calcium dependent) to C-polysaccharide in bacterial cell walls
What is High sensitivity CRP (hs-CRP)?
Used to assess risk for acute coronary syndrome
Stimulated by IL-6 during inflammation
Increases are minimal
Often less than reference range for conventional CRP
What does elevated hs-CRP indicate?
Baseline elevations indicate higher risk for coronary artery disease and death from CAD with or without presence of clinical symptoms.
What do treatments to decrease inflammation may also reduce?
Aspirin or other anti-inflammatory drugs reduce risk of coronary artery disease
What is does it mean to have 0-1 mg/L of hs-CRP?
Low risk for acute coronary syndrome
What is does it mean to have 1-3 mg/L of hs-CRP?
Moderate risk for acute coronary syndrome
What is does it mean to have anything over 3mg/L of hs-CRP?
High risk for acute coronary syndrome.
What must be performed with hs-CRP to detect minimal changes?
High sensitivity methods
What are some methods for conventional laboratory detection of CRP?
Anti-human CRP attached to latex particle
Precipitation (capillary or tube)
What are the characteristics of CRP assays?
Reference range: < 0.5 mg/dL
sensitive to 3mg/L
What are some methods for laboratory detection of hs-CRP?
Uses monoclonal antibody to CRP
Sensitive to 0.175 mg/L
THIS SET IS OFTEN IN FOLDERS WITH...
Miscellaneous Immunologic Techniques
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