5 Written questions
5 Matching questions
- tinidazole, metronidazole
- hydrochlorothiazide, indapamide
- a Antihypertensive vasodilator (mainly arteriolar). Increases K+ permeability. May also be used as cream for baldness.
- b non-azole antifungal that inhibits ergosterol synthese via squalene epoxidase
- c thiazide diuretics (act on distal tubule, increase Na+ and K+ excretion, decrease Ca+ excretion. initially reduced CO, longer term normal CO, decreased TPR). Used for hypertension, diabetes insipidus, and oedema due to CHF, renal or hepatic disease.
- d Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
- e G-CSF. Stimulates production and function of neutrophils. Used after cancer chemotherapy, bone marrow transplant and in AML.
5 Multiple choice questions
- short acting beta agonists (relievers for asthma).
- long acting beta agonists (symptom controllers for asthma). contraindicated with antihypertensives.
- PD drug (mild relief in early stage PD), action unclear.
- Antiplatelet. Blocks ADP receptor on platelets, therefore inhibits ADP-induced platelet aggregation. May cause severe bleeding.
- Centrally acting alpha2 adrenoreceptor agonists (sympathetic inhib). Vasodilatory. Rarely used for hypertension. SEs: sedation, depression, rebound HT on withdrawal
5 True/False questions
praziquantel → Antihelmintic- treatment of intestinal tapeworms (cestodes). Causes tetanic-like contractions in worm muscle by altering calcium permeability, worms detached from host tissue.
salbutamol → short acting beta agonist (reliever for asthma). also called ventolin.
Also, relaxation of uterine smooth muscle (e.g. delays preterm labour - but mainly nifedipine, a calcium channel blocker, is used). SE: skeletal muscle tremor.
ketoconazole → an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.
selegiline → Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
class III antiarrhythmics → B blockers used post-MI and for AF e.g. propranolol, atenolol, metoprolol