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5 Written questions

5 Matching questions

  1. minoxidil
  2. filgrastim
  3. terbinafine
  4. tinidazole, metronidazole
  5. hydrochlorothiazide, indapamide
  1. a Antihypertensive vasodilator (mainly arteriolar). Increases K+ permeability. May also be used as cream for baldness.
  2. b non-azole antifungal that inhibits ergosterol synthese via squalene epoxidase
  3. c thiazide diuretics (act on distal tubule, increase Na+ and K+ excretion, decrease Ca+ excretion. initially reduced CO, longer term normal CO, decreased TPR). Used for hypertension, diabetes insipidus, and oedema due to CHF, renal or hepatic disease.
  4. d Antiprotozoal e.g. amoebiasis, giardiasis, trichomoniasis. Also used for some bacterial anaerobes. Nitroimidazoles, interfere with DNA synthesis. e.g. trichomonas vaginalis
  5. e G-CSF. Stimulates production and function of neutrophils. Used after cancer chemotherapy, bone marrow transplant and in AML.

5 Multiple choice questions

  1. short acting beta agonists (relievers for asthma).
  2. long acting beta agonists (symptom controllers for asthma). contraindicated with antihypertensives.
  3. PD drug (mild relief in early stage PD), action unclear.
  4. Antiplatelet. Blocks ADP receptor on platelets, therefore inhibits ADP-induced platelet aggregation. May cause severe bleeding.
  5. Centrally acting alpha2 adrenoreceptor agonists (sympathetic inhib). Vasodilatory. Rarely used for hypertension. SEs: sedation, depression, rebound HT on withdrawal

5 True/False questions

  1. praziquantelAntihelmintic- treatment of intestinal tapeworms (cestodes). Causes tetanic-like contractions in worm muscle by altering calcium permeability, worms detached from host tissue.

          

  2. salbutamolshort acting beta agonist (reliever for asthma). also called ventolin.
    Also, relaxation of uterine smooth muscle (e.g. delays preterm labour - but mainly nifedipine, a calcium channel blocker, is used). SE: skeletal muscle tremor.

          

  3. ketoconazolean imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.

          

  4. selegilineIron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)

          

  5. class III antiarrhythmicsB blockers used post-MI and for AF e.g. propranolol, atenolol, metoprolol