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5 Written questions

5 Matching questions

  1. streptokinase
  2. amiodarone
  3. catopril, enlapril, perindopril
  4. digoxin
  5. propanolol
  1. a cardiac glycoside that increases myocardial contractility (by increasing myocardial intracellular calcium) and stimulates vagus nerve (slows AV conduction). used for heart failure and AF. contraindicated with loop and thiazide diuretics and sympathomimetic drugs. narrow safety margin
  2. b non- selective B1 and B2 antagonist used for angina, arrhythmia (class II) and hypertension
  3. c class III antiarrhythmic. prolongs refractory period and slows AV conduction. serious side effects (thyroid, lungs, liver)
  4. d Fibrinolytic. Activates plasminogen (which converts fibrin to fibrin degradation products). Indications: AMI, PE
  5. e ACE inhibitors (type of RAS inhibitor used in heart failure hypertension and diabetic nephropathy). SEs: hypotension, hyperkalaemia, cough. Reduce TPR, hypertension and increase sodium and water excretion. Contraindicated in pregnancy and renal artery stenosis.

5 Multiple choice questions

  1. Non-selective alpha 1+2 adrenoreceptor blocker in smooth muscle. Vasodilation. Used in phaeochromocytoma (HT due to adrenal tumor) and erectile dysfunction. SEs: first dose syncope, postural hypotension, reflex tachycardia, urinary urgency,
  2. antifungal that targets cell wall synthesis - IV use only for invasive aspergillosis
  3. loop diuretics (act on thick ascending limb to block Na+/K+2Cl- transporter). Used for salt/ water overload associated with acute pulmonary oedema, CHF, liver cirrhosis and renal failure.
  4. parenteral iron therapy (IM or IV). Indications: unable to absorbe oral iron in iron deficiency. SEs: fever, arthralgia, nausea, abdominal cramps, vomiting
  5. Centrally acting alpha2 adrenoreceptor agonists (sympathetic inhib). Vasodilatory. Rarely used for hypertension. SEs: sedation, depression, rebound HT on withdrawal

5 True/False questions

  1. mannitolAntihypertensive. Osmotic diuretic, acts on whole nephron. Blocks tubular water resorption and reduces Na+ resorption rate.

          

  2. sargramostimGM-CSF. Used to treat neutropenia in chemotherapy and after bone marrow transplant.

          

  3. amantidinePD drug (mild relief in early stage PD), action unclear.

          

  4. ketoconazolean imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Causes liver toxicity and inhibits steroidogenesis.

          

  5. tetrabenazineBenzimidazole - antihelmintic for intestinal nematodes e.g. threadworm, hookworm, whipworm, roundworm. Impairs microtubule synthesis.
    Pooly absorbed from GIT, few SEs.