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5 Written questions

5 Matching questions

  1. salmeterol, eformoterol
  2. filgrastim
  3. mannitol
  4. amantidine
  5. tolcapone, entacapone
  1. a G-CSF. Stimulates production and function of neutrophils. Used after cancer chemotherapy, bone marrow transplant and in AML.
  2. b PD drug (mild relief in early stage PD), action unclear.
  3. c COMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.
  4. d Antihypertensive. Osmotic diuretic, acts on whole nephron. Blocks tubular water resorption and reduces Na+ resorption rate.
  5. e long acting beta agonists (symptom controllers for asthma). contraindicated with antihypertensives.

5 Multiple choice questions

  1. mast cell stabilisers (preventers for asthma)
  2. cardioselective calcium channel blockers (decreased contractility, induce vasodilation) used for angina, hypertension and arrhythmia
  3. Antiepileptic. GABA agonist (inhibits GABA - t, which metabolises GABA), and also blocks high freq firing through Na+ channels. 1st line in generalised seizures (both TONIC-CLONIC and absence), 2nd line in PARTIAL seziures. SEs: weight gain, alopecia, cyp450 inhibition, spina bifida in foetuses

    ALSO used as mood stabiliser in acute manic phase of bipolar disorder (particuarly with patients that rapidly cycle through manic depressive phases)
  4. sodium channel blocker potassium sparing diuretics (act on late DCT and collecting tubules). Used with thiazide or loop diuretics to produce diuresis without hypokalaemia, and with thiazides as antihypertensives.
  5. DA agonist (directly stimulates D2 receptors in PD). SEs: nausea, hypotension, psychological effects, pleural effusions, retroperitoneal fibrosis, vasospasm. Used in combination with levodopa (reduces wearing off symptoms).

5 True/False questions

  1. dobutamineB1 adrenoreceptor agonist sometimes used in heart failure (increased contractility and cardiac output)

          

  2. aspirinAnticoagulant, enhances action of antithrombin III (binds to clotting factors). Use acutely for DVT, PE, surgery, unstable angina.

          

  3. fluticasone, budesonidecorticosteroids (preventers for asthma)

          

  4. carbidopa, benserazideAntiepileptic. Use-dependent Na+ blockade. 1st line for partial and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, bone marrow depression

    ALSO used as mood stabiliser in acute manic phase of bipolar disorder (particuarly with patients that rapidly cycle through manic depressive phases)

          

  5. hydralazineDepletes DA within brain, used for Huntington's disease.