5 Written questions
5 Matching questions
- fluticasone, budesonide
- amiloride, triamterene
- a cardiac glycoside that increases myocardial contractility (by increasing myocardial intracellular calcium) and stimulates vagus nerve (slows AV conduction). used for heart failure and AF. contraindicated with loop and thiazide diuretics and sympathomimetic drugs. narrow safety margin
- b short acting beta agonist (reliever for asthma). also called ventolin.
Also, relaxation of uterine smooth muscle (e.g. delays preterm labour - but mainly nifedipine, a calcium channel blocker, is used). SE: skeletal muscle tremor.
- c GABA agonist used for Huntington's disease.
- d sodium channel blocker potassium sparing diuretics (act on late DCT and collecting tubules). Used with thiazide or loop diuretics to produce diuresis without hypokalaemia, and with thiazides as antihypertensives.
- e corticosteroids (preventers for asthma)
5 Multiple choice questions
- long acting beta agonists (symptom controllers for asthma). contraindicated with antihypertensives.
- Anticoagulant, vitamin K antagonist (inhibits factors 2, 7, 9, 10). Indications: PE, DVT (ongoing treatment), unstable angina, AF.
- local anasthethics used for ventricular arrhythmias (block fast sodium current, slow cardiac conduction) e.g. lignocaine, quinidine, flecainide, procainamide
- longer term nitrate for angina, given subligually and orally
- Fibrinolytic. Plasminogen activator. Used only in acute thrombotic or embolic stroke.
5 True/False questions
amiodarone → antifungal that disrupts cell membrane synthesis. used in laquer for nails to treat onychomycoses
praziquantel → class of drugs for angina that increase venous, arteriolar and coronary dilation e.g. isosorbide dinitrate and nitroglycerin (not to be used with viagra)
iron- dextran, iron- sucrose → parenteral iron therapy (IM or IV). Indications: unable to absorbe oral iron in iron deficiency. SEs: fever, arthralgia, nausea, abdominal cramps, vomiting
desferrioxamine → Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
amphotericin → polyene antifungal (disrupts cell membrane integrity by binding to ergosterol) used for asperigillus and candida (orally, IV, topically)