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5 Written questions

5 Matching questions

  1. sargramostim
  2. clotrimazole
  3. hydralazine
  4. baclofen
  5. mannitol
  1. a an imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - only used topically (vaginal/ skin)
  2. b Antihypertensive. Osmotic diuretic, acts on whole nephron. Blocks tubular water resorption and reduces Na+ resorption rate.
  3. c Antihypertensive (esp. in emergency) vasodilator (mainly arteriolar). Interferes with IP3 on Ca release from SR.
  4. d GABA agonist used for Huntington's disease.
  5. e GM-CSF. Used to treat neutropenia in chemotherapy and after bone marrow transplant.

5 Multiple choice questions

  1. Antiplatelet. Monoclonal antibody that antagonises GIIb/a receptor on platelets, prevents binding of fibrinogen to platelets. Hospital use only.
  2. ACE inhibitors (type of RAS inhibitor used in heart failure hypertension and diabetic nephropathy). SEs: hypotension, hyperkalaemia, cough. Reduce TPR, hypertension and increase sodium and water excretion. Contraindicated in pregnancy and renal artery stenosis.
  3. Vasopressin analogue. Normalises haemostasis in vWD for several hours, used for minor procedures such as dental extraction.
  4. Iron chelator. For acute iron toxicity or haemachromatosis, forms a complex with ferric iron and is excreted in urine. Orally absorbed, careful monitoring required (risk of agranulocytosis)
  5. Antiepileptic. Use-dependent Na+ blockade. 2nd line for PARTIAL and generalised TONIC-CLONIC seizures. SEs: cyp450 inducer, gum hyperplasia/ acne/ hirsuitism, fetal - affects palate and heart

5 True/False questions

  1. praziquantelclass of drugs for angina that increase venous, arteriolar and coronary dilation e.g. isosorbide dinitrate and nitroglycerin (not to be used with viagra)

          

  2. amiodaroneclass III antiarrhythmic. prolongs refractory period and slows AV conduction. serious side effects (thyroid, lungs, liver)

          

  3. minoxidilAntihypertensive vasodilator (mainly arteriolar). Increases K+ permeability. May also be used as cream for baldness.

          

  4. isosartan, candsartanangiotensin AT1 receptor antagonists (type of RAS inhibitor used in heart failure, hypertension and diabetic nephropathy). SEs: hypotension, hyperkalaemia. reduce TPR, hypertension and increase sodium and water excretion. Contraindicated in pregnancy and renal artery stenosis.

          

  5. filgrastimpolyene antifungal (disrupts cell membrane integrity by binding to ergosterol) only used topically e.g. candida albicans

          

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