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5 Written questions

5 Matching questions

  1. class II antiarrhythmics
  2. catopril, enlapril, perindopril
  3. fluconazole
  4. cryoprecipitate
  5. dobutamine
  1. a ACE inhibitors (type of RAS inhibitor used in heart failure hypertension and diabetic nephropathy). SEs: hypotension, hyperkalaemia, cough. Reduce TPR, hypertension and increase sodium and water excretion. Contraindicated in pregnancy and renal artery stenosis.
  2. b a triazole antifungal (targets ergosterol synthesis via 14-aemethylase) - used topically and orally. Penetrates well into brain - used for cryptococcal meningitis
  3. c Obtained from blood donations. Contains concentrated vWF, given in severe vWD.
  4. d B blockers used post-MI and for AF e.g. propranolol, atenolol, metoprolol
  5. e B1 adrenoreceptor agonist sometimes used in heart failure (increased contractility and cardiac output)

5 Multiple choice questions

  1. Oral iron therapy for iron deficiency anaemia. Continued for 2 - 3 months. SEs: nausea, abdominal cramps, constipation/ diarrhoea
  2. COMT inhibitors, used alone or with levodopa and DDCIs (prolongs half life of levodopa). Used in PD.
  3. Centrally acting alpha2 adrenoreceptor agonists (sympathetic inhib). Vasodilatory. Rarely used for hypertension. SEs: sedation, depression, rebound HT on withdrawal
  4. short acting beta agonists (relievers for asthma).
  5. Non-selective alpha 1+2 adrenoreceptor blocker in smooth muscle. Vasodilation. Used in phaeochromocytoma (HT due to adrenal tumor) and erectile dysfunction. SEs: first dose syncope, postural hypotension, reflex tachycardia, urinary urgency,

5 True/False questions

  1. clotrimazolean imidazole antifungal (targets ergosterol synthesis via 14-aemethylase) - only used topically (vaginal/ skin)

          

  2. carbamazapinenon-azole antifungal that inhibits ergosterol synthese via squalene epoxidase

          

  3. atenolol, metoprolollong acting beta agonists (symptom controllers for asthma). contraindicated with antihypertensives.

          

  4. polyenesEndothelin (vasoconstrictor) receptor antagonist (mixed ETa and ETb antag, vasodilatory). Not effective in primary hypertension, used in pulmonary hypertension.

          

  5. bosentanEndothelin (vasoconstrictor) receptor antagonist (mixed ETa and ETb antag, vasodilatory). Not effective in primary hypertension, used in pulmonary hypertension.