Immune System 2

Section 2 Worksheet
2 major anatomical parts of the immune system
1) Specialized immune cells (ex. leukocytes)
2) Lymphoid organs and tissues (ex. bone marrow)
Cells of the immune system originate in ________. These cells are called ______ when traveling in the blood and are classified according to the shape of their nucleus and the colors of their granules when stained.
Bone marrow, leukocytes
Multilobed nucleus
Pale-staining granules
Small leukocyte, round nucleus
No prominent granules
large leukocyte, U-shape nucleus
no prominent granules
Bilobed nucleus with granules
No prominent granules
Large granules hide lobed nucleus
stains blue/purple
Neutrophils (blood
Macrophages (tissue)
Antigen-presenting cells
Dendritic cells (tissue)
Macrophages (tissue)
B cells (blood)
Effector Cells of adaptive immunity
B and T cells (blood)
Other Specialized Immune Cells
Mast Cells (tissue)
Both B and T cells originate from _______.
Bone Marrow
The B cells mature in the _________.
Bone marrow
The T cells mature in the ________.
Secondary Lymphoid Organs
A) Lymph nodes
B) Spleen
C) Peyer's patches
D) Appendix
E) Tonsils
3 Parts of the Lymphatic System
1) Lymphatic Vessels
2) Lymph
3) Lymph Nodes
How many liters or interstitial fluid is returned to the cardiovascular system per day?
3 L/Day
If lymphatic vessels do not function properly, there will be a buildup of fluid in the tissues. This condition is called ________.
The lymphatic capillaries have ______ valves to collect the excess interstitial fluid and any leaked proteins.
The lymph is filtered through the _________ where antigens and pathogens are removed and the immune system can be activated.
Lymph Nodes
Special lymphatic capillaires in the intestines, called ______, transport absorbed ______ from the intestines into the blood.
Lacteals, Fat
2 Functions of the lymph nodes
1) removal of antigens and other debris
2) activation of the immune system (B and T cells)
While _____ lymphatic vessels carry lymph from the tissues to the lymph nodes, _______ vessels carry cleansed lymph away from the lymph nodes.
afferent, efferent
___ cells are found in the germinal centers of lymphoid follicles, and ____ cells wander through the deep _____, searching dendritic cells for their special antigen.
B, T, Cortex
3 Functions of the Spleen
1) Removes pathogens, aged erythrocytes and platelets
2) Stores platelets and breakdown products of erythrocytes
3) Site for activation of the immune system
mucosa-associated lymphoid tissue
-peyer's patches, tonsils, appendix
-respiratory system
The ______, a primary lymphoid organ, is the site for differentiation of lymphocytes into mature T cells.
What happens to the thymus as we age?
The thymus decreases in size and activity