1) Specialized immune cells (ex. leukocytes) 2) Lymphoid organs and tissues (ex. bone marrow)
Cells of the immune system originate in ________. These cells are called ______ when traveling in the blood and are classified according to the shape of their nucleus and the colors of their granules when stained.
Bone marrow, leukocytes
Multilobed nucleus Pale-staining granules
Small leukocyte, round nucleus No prominent granules
large leukocyte, U-shape nucleus no prominent granules
Bilobed nucleus with granules No prominent granules
Large granules hide lobed nucleus stains blue/purple
Neutrophils (blood Macrophages (tissue)
Dendritic cells (tissue) Macrophages (tissue) B cells (blood)
Effector Cells of adaptive immunity
B and T cells (blood)
Other Specialized Immune Cells
Mast Cells (tissue)
Both B and T cells originate from _______.
The B cells mature in the _________.
The T cells mature in the ________.
Secondary Lymphoid Organs
A) Lymph nodes B) Spleen C) Peyer's patches D) Appendix E) Tonsils
3 Parts of the Lymphatic System
1) Lymphatic Vessels 2) Lymph 3) Lymph Nodes
How many liters or interstitial fluid is returned to the cardiovascular system per day?
If lymphatic vessels do not function properly, there will be a buildup of fluid in the tissues. This condition is called ________.
The lymphatic capillaries have ______ valves to collect the excess interstitial fluid and any leaked proteins.
The lymph is filtered through the _________ where antigens and pathogens are removed and the immune system can be activated.
Special lymphatic capillaires in the intestines, called ______, transport absorbed ______ from the intestines into the blood.
2 Functions of the lymph nodes
1) removal of antigens and other debris 2) activation of the immune system (B and T cells)
While _____ lymphatic vessels carry lymph from the tissues to the lymph nodes, _______ vessels carry cleansed lymph away from the lymph nodes.
___ cells are found in the germinal centers of lymphoid follicles, and ____ cells wander through the deep _____, searching dendritic cells for their special antigen.
B, T, Cortex
3 Functions of the Spleen
1) Removes pathogens, aged erythrocytes and platelets 2) Stores platelets and breakdown products of erythrocytes 3) Site for activation of the immune system
mucosa-associated lymphoid tissue -peyer's patches, tonsils, appendix -respiratory system
The ______, a primary lymphoid organ, is the site for differentiation of lymphocytes into mature T cells.