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Tx of myxyedema coma in dogs
L-thyroxine sodium for injection IV or SC; warming the animal; artificial respiration; fluid, electrolytes, glucocorticoids for shock
Drugs that decrease thyroid levels
glucocorticoids, sulfonamides, anticonvulsants, phenylbutazone, salicylates, quinidine, mitotane, general anesthetics
thioureylenes (methimazole, propylthiouracil), iodides (lugol's iodine, potassium iodide), iodinated radiographic contrast agents (ipodate), antithyroid plants (cabbage, turnip, broccoli, and rapeseed)
inhibit thyroid hormone organification, inhibit preformed hormone secretion, reduce the size and vascularity of the thyroid gland, may inhibit the binding of iodine
MOA iodinated radiographic contrast agents
inhibits conversion of T4 and T3 in peripheral tissues, inhibit thyroid hormone synthesis and release
Tx of hyperthyroidism in cats
sx thyroidectomy, radioactive iodine, antithyroid drugs, beta blockers
Radioactive iodine therapy
selectively destroys thyroid tissue; has a 1/2 life of 8 days; treated cats must be hospitalized for 1-4 wks; can produce a premanent cure w/o sx; also used for thyroid adenocarcinoma; very safe, but very expensive
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