15 terms

Pharmacology: Pain (ATI NCLEX Review)

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What drugs used concurrently with acetaminophen may increase hepatotoxic effects?
Rifampin, INH (used to treat TB), carbamazepine, barbiturates
How does acetaminophen impact warfarin?
Slows metabolism of warfarin
What drug is used to treat acetaminophen overdose?
acetylcysteine
What is the maximum amount of acetaminophen one can take in 24 hours?
4000 mg
What organ functions need to be monitored with acetaminophen use?
Kidney, liver
What are major side effects of opioid analgesic use?
constipation, urinary retention, orthostatic hypotension, blurred vision, respiratory depression, abstinence syndrome
What drug classes can potentiate the effects of opioid analgesics?
Barbiturates, benzodiazepines, phenothiazines, hypnotics, sedatives
What should the nurse monitor in a patient taking opioid analgesics?
vital signs, respiratory depression, urinary retention
What is the antidote for opioid overdose?
Naloxone
What class of drugs do fentanyl, hydromorphone, morphine, meperidine, and codeine belong to?
Opioid analgesics
What may nonaspirin NSAIDs increase the risk of?
MI and stroke
What are 4 main adverse effects of NSAID use?
GI discomfort, GI ulceration, renal impairment, photosensitivity
Should NSAIDs be taken on an empty stomach?
No - they should be administered with food and full glass of water
What should the nurse advise patients to avoid doing after taking NSAIDs?
Avoid lying down for 30 mins. Avoid overuse to prevent GI ulceration
What is a major risk of continued NSAID use?
GI ulceration