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Terms in this set (34)
What are antibodies produced in response to bacterial infections (gram-) in which fever is prominent feature and are usually difficult to grow in laboratory cultures?
What are the characteristics of microorganisms that can elicit production of febrile agglutinins?
They can produce persistent fever, frequently difficult to grow in lab cultures and difficult to interpret due to cross-reactivity of antigens, production of heterologous antibodies, prior immunization of patient and prozone reactions.
What are some of the febrile antigens?
Salmonella O antigens, Brucella abortus antigen, Proteus OX-19, OX-2, OX-K and Franisella tularensis antigen.
What are the groups of Salmonella O antigens?
Group A, B, D and flagellar a, b and d.
Which antigen is associated with paratyphoid A?
Salmonella O antigens: Group A.
Which antigen is associated with paratyphoid B?
Salmonella O antigens: Group B.
Which antigen is associated with typhoid O?
Salmonella O antigens: Group D.
Which antigen is associated with typhoid H?
Salmonella O antigens: flagellar a, b and d.
Which antigen/organism is associated with the gram negative bacilli found in the normal flora of genital and urinary tracts of pigs, cows and dogs, can survive intracellularly (primary virulence factor) and cause chronic, relapsing febrile disease, granuloma and abscess formation?
Which antigen is associated with rickettsial disease?
Proteus OX-2, 19, and K.
Which antigen/organism is a gram(-) microorganism with a capsule that is very invasive can penetrate skin, survive phagocytosis and cause human tularemia?
What is testing for febrile diseases used for?
Diagnosing typhoid fever, brucellosis, tularemia and rickettsial diseases.
What are the serological test used in testing for febrile diseases?
The Widal Reaction and the Weil-Felix test.
Which test is devised for the diagnosis of typhoid fever?
Which test uses antigens prepared from a species of proteus to detect related rikettsial antibodies?
What can give presumptive evidence for diagnosis when testing for febrile diseases?
Rising titer of specific agglutinin along with clinical symptoms.
What can microbial isolation or more specific antibody methods do when testing for febrile diseases?
Give a definitive diagnosis.
What principle involves incubating the patient serum with antigen under properly controlled conditions resulting in visible agglutination in the presence of the antigen with the results being compared to controls and read (-), 1+, 2+, 3+, etc.?
Serological testing for febrile diseases.
What can be performed with positive test?
Which test is an agglutination test for antibodies to Salmonella H & O antigens, Brucella, Francisella and bordetellla using salmonella bacteria to detect antibodies in paratyphoid and typhoid fevers?
What are the antibodies detected in the Widal Reaction?
Antibodies to Salmonella H (flagellar) and O (cell wall) antigens.
Which test is based on the fact that certain strains of Proteus vulgaris most probably share antigens with several of the Rickettsia species that produce febrile diseases?
Which test use 3 strains (OX-2, 19 and K) of Proteus vulgaris to detect antibodies against several diseases?
Which diseases shows signs and symptoms that include malaise, chills, fever, mental changes, localized lesions in any organ and febrile antibodies appearing in 2-3 weeks after infection?
Which disease is carried by wild rodents, rabbits, beavers, is transmitted by handling dead carcasses of infected animals, inhalation or bites of carnivores that have ingested infected animals and have deer flies and ticks as insect vectors?
Which disease have signs and symptoms that include high fever, headaches, lymphadenopathy, ulcerative lesions at site of inoculation, pneumonia is a frequent complication and possible granulomatous lesions in various organs?
What has a detectable antibody in 2 - 3 weeks having titers > 1:160 considered significant (Reference range: < 1:20) an average titer of 1:640 within 5 weeks, a 4-fold titer increase in samples @ 1-2 week intervals and specific IgG, IgA persists for years and is a slow growing organism?
Diagnosis of Tularemia.
What are the serologic test used in diagnosis of Tularemia?
C' fixation and EIA for specific IgM and IgG (method of choice).
Which disease have signs and symptoms which include fever, headache, cough, splenomegaly, leukopenia and relapse in 5-10% of patients?
What febrile antigen has five groups based on O antigens (cell wall) and 1200 serotypes based on H antigens (flagellar)?
What has febrile agglutinins appear in 7-10 days using the Widal test to look for agglutination using Salmonella O antigens?
Serologic diagnosis of typhoid fever.
What disease causes typhus fevers and rocky mountain spotted fever which from a gram(-) bacilli that infects wild animals and is transmitted to humans by an insect vector?
What disease have signs and symptoms which includes fever, rash and a history of tick bites?
What has antibodies that appear in 7-10 days after infection using the Weil-felix reactions to test with Proteus OX-2, 19 and K antigens for agglutination and use pattern to determine disease?
Serologic diagnosis of Rickettsial disease.
THIS SET IS OFTEN IN FOLDERS WITH...
Primary and secondary immunodeficiency states
Misc. Infectious Disease
Weil-Felix Reactions in Rickettsial Diseases
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