What is the mechanism of action for Succinylcholine?
Depolarizing Muscle Relaxant - mimics ACh causing prolonged depolarization at the NMJ and paralysis secondary to blocked ACh receptors
What is the intubating dose for Succinylcholine?
How fast is the onset for Succinylcholine?
How long does Succinylcholine last?
How is Succinylcholine metabolized?
What are the indications for using Succinylcholine?
- Rapid Sequence Induction - Short procedures (small) - Laryngospasm
What are the side effects of Succinylcholine?
- stimulates muscarinic as well as nicotinic, so can result in bradycardia, dysrhythmias - hyperkalemia (stimulation leads to massive release of potassium from muscle cells) - triggers MH - increases ICP - fasciculations (can be minimized by using roc)
Contraindications to Succinylcholine
Absolute: - history of above complications - myotonia Relative: - plasma cholinesterase deficiency - myaesthenias
Mechanism of action of Ketamine?
Phenylcyclidine derivative - acts on opioid, NMDA, other receptors
What are the effects of Ketamine to the CVS, CNS, and respiratory system?