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ATI Intro to Pharm CV
Terms in this set (9)
Drug Therapy for Hypertension
Calcium channel blockers
four types of RAAS suppressants
support the treatment of hypertension:
Direct renin inhibitors
Left ventricular dysfunction following myocardial infarction
ACE Inhibitors: Prototype
Prototype drug: captopril (Capoten)
ACE Inhibitor: Pharm Action
*Blocks production of angiotensin II
*Urinary excretion of sodium and water
*Urinary retention of potassium
ACE Inhibitor: Side Effects
Severe hypotension following first dose
Dry, nonproductive cough due to increase in bradykinin
Angioedema (swelling of mouth, throat due to inhibition of kinase II)
Rash and report of metallic taste in mouth
ACE Inhibitors: Interventions
-Start ACE inhibitors with low dose; gradually increase.
-Diuretics may be temporarily stopped before first dose.
-Monitor blood pressure closely following first dose.
-Monitor for and report dry cough, rash, and metallic taste in mouth.
-Monitor for angioedema; treat with IV epinephrine.
-Monitor potassium levels and white blood cell counts.
ACE Inhibitors: Administration
-Available for oral use only.
-Must be taken two to three times daily for hypertension; three times daily for heart failure.
-Give captopril 1 hr before meals for adequate absorption
ACE Inhibitors: Instructions
-Be aware that hypotension may occur.
-Report dry cough, rash, and metallic taste in mouth to provider.
Report minor swelling of mouth, throat; call 911 immediately if severe.
Refrain from using potassium supplements and potassium-containing salt.
Report palpitations, muscle twitching, weakness, or paresthesias.
Report sore throat or other signs of infection.
Do not take an ACE inhibitor if you are pregnant or breast feeding.
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