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Pancreas of 22 yr old caucasian male with recurrent pulmonary infections and finger clubbing shows extensive exocrine gland atrophy and fibrosis. Pancreatic ducts are lined with squamous epithelium with areas of keratinization. This finding of squamous metaplasia in the pancreatic duct is due to what deficiency?
Vitamin A deficiency. Recurrent sinopulmonary infections + exocrine gland fibrotic atrophy
in young caucasian is suggestive of Cystic fibrosis. Severe CF may cause total obstruction followed by complete fibrotic atrophy resuilting in pancreatic insufficiency which causes a deficiency of fat soluble vitamins.
levels and its metabolite retinoic acid are needed to maintain differentiation of specialized eptihelia like mucus secreting columnar so if when a deficiency exists it can turn to
Deficiency in Vitamins A, D, E, K, and Riboflavin would cause what conditions respectively?
Vit A deficiency
can be caused by Cystic fibrosis leading to pancreatic insufficency, fat malabsopriton and deficiency of vitamins ADEK, but
Vit A deficiency could cause squamous metaplasia to a keratinizng epithelia since Vit A maintains orderly differentiation of specialized epithelia eg mucus secreting columnar epithelia
Vit D deficeincy could produce
rickets in children
osteomalacia in adults
Vit E deficiency could cause
decrease in some serum phospholipids
Vit K deficiency could cause
coagulopathy (bleeding diathesis) secondary to ineadequate vitamin K dependent clotting factors
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