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76 terms

Veterinary Science:Parasitology-Pharmacology-Modes of Action

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What target these drugs share, Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad?
Synapse
What MOA do these drugs share, Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad?
Activate acetylcholine receptors
What parasite group(s) are Nicotine, levamisole, pyrantel, oxantel, imidacloprid, nitenpyram, spinosad, effective against?
helminths, arthropods
What is the traget of Organochlorines, phenyl pyrazoles?
Synapse
What is the Mode of Action of Organochlorines, phenyl pyrazoles?
Block GABA-gated Cl- channels
What are Organochlorines, phenyl pyrazoles effective against?
arthropods
What is the target of Piperazine?
Synapse
What is the Mode of Action of Piperazine?
Activate GABA-gated Cl- channels
What parasite group is Piperazine effective against?
nematodes
What target are Macrocyclic lactones aimed at?
Synapse
What is the Mode of Action of Macrocyclic lactones?
Activate glutamate-gated Cl- receptors
What parasite group(s) are Macrocyclic Lactones effective against?
helminths and arthropods
What is the target of Organophosphates, carbamates?
Synapse
What is the Mode of Action of Organophosphates, carbamates?
ACh'estase inhibitor
What parasitic groups are Organophosphates, carbamates effective against?
arthropods, nematodes
What is the target of Emodepside?
Synapse
What is the Mode of Action of Emodepside?
Activate latrophilin receptor
What is Emodepside effective against?
nematodes
What is the target of Amitraz?
CNS
What is the mode of action of Amitraz?
activate octopamine receptors
What parasite group is Amitraz effective against?
acarines
What is the target of pyrethroids, organochlorines, metaflumizone?
nerve fibres
What is the Mode of Action of Pyrethroids, organochlorines, metaflumizone?
prolong Na+ chennel opening
What parasitic group are Pyrethroids, organochlorines, metaflumizone effective against?
arthroppods
What is the target of Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol?
cellular respiration
What is the Mode of Action of Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol?
inhibit e-transport, uncouple ATP production
What parasite groups are Rotenone, dinitrophenol, atovaquone, decoquinate, dichlorophene, salicylanilides, nitrophenol effective agasints?
arthropods, helminths, protozoa
What is the target of Benzimidazoles?
Microtubules
What is the Mode of Action of Benzimidazoles?
inhibit syntheses of microtubles by binding to B-tubulin
What parasite groups are Benzimidazoles effective against?
helminths, protoza
What is the target of Benzylphenylureas?
Chittin synthesis
What it the Mode of Action of Benzylphenylureas?
Inibition of chittin synthesis
What parasite groups is Benzylphenylureas effective against?
arthropods
What is the target of Cyromazine, methoprene, pyriproxyfen, dicyclanil?
Moulting
What is the Mode of Action for Cyromazine, methoprene, pyriproxyfen, dicyclanil?
Juvenile hormone agonoists, Triazines
What parasitic groups are Cyromazine, methoprene, pyriproxyfen, dicyclanil effective against?
arthropods
What is the target of Action of Praziquantel, epsiprantel?
cell function
What is the Mode of Action of Praziquantel, epsiprantel?
Activate voltage-gated Ca+ channels
What are Praziquantel, epsiprantel effective against?
Platyhelminths
What is the target of Clorsulon?
Glycolysis
What is the Mode of Action of Clorsulon?
Inhibition of glycolysis
What parasite groups is Clorsulon effective against?
trematodes
What is the target of Piperonyl butoxide?
Mixed Function Oxidases
What is the Mode of Action for Piperonyl butoxide?
Inhibition of MFO
What parasitic group(s) are Piperonyl butoxide effective against?
arthropods
What is the target of Sodium ionophores?
Cell function
What is the Mode of Action of Sodium ionophores?
Promote intracellular uptake of Na+ and H+
What parastic groups are Sodium ionophores effective against?
Protozoa, coccidia
What is the target of Melarsomine?
Protein denaturing
What is the Mode of Action of Melarsomine?
Binds to cystine
What parasitic group is Melarsomine effective against?
filaria
What is the target of Sulphonamides, trimethoprim, pyrimethamine?
Folic acid
What is the mode of action of Sulphonamides, trimethoprim, pyrimethamine?
Inhibit synthesis, metabolism of Folic Acid
What parasitic groups are Sulphonamides, trimethoprim, pyrimethamine effective against?
protozoa
What is the target of Amprolium?
Thiamine
What is the mode of action of Amprolium
Inhibit utilisation
What parasitic groups is Amprolium effective against?
protozoa
What is the target of Aromatic diamidines (imidocarb), quinacrine?
DNA
What is the Mode of Action of Aromatic diamidines (imidocarb), quinacrine?
DNA, RNA binding
What parasitic groups are Aromatic diamidines (imidocarb), quinacrine effective against?
protoza
What is the target of Metronidazole, dimetridazole?
DNA
What is the Mode of Action of Metronidazole, dimetridazole?
DNA synthesis
What parasitic groups are Metronidazole, dimetridazole effective against?
protozoa
What is the target of Clindamycin?
Protein synthesis
What it the Mode of Action of Clindamycin?
Binds to ribosomes
What parasitic groups are Clindamycin effective against?
protozoa
What is the target of B. Thuringensis toxin?
Gut
What is the Mode of Action of B. Thuringensis toxin?
Direct damage to cells in the Gut
What parasitic groups is B. Thuringensis toxin effective against?
Arthropods, helminths
What is the target of Diclazuril, tolrazuril, ponazuril?
Nuclear division
What is the Mode of Action of Diclazuril, tolrazuril, ponazuril?
inhibit nuclear division
What parasitic groups are Diclazuril, tolrazuril, ponazuril effective against?
protozoa
What is the target of Nicarbazin
Unknown
What is the Mode of Action of Nicarbazin?
unknown
What parasite groups are Nicarbazin effective against?
protozoa
Who is acknowledged for this content of these questions?
Prof Jim Rothwell, School of Veterinary Science, University of Queensland (Gatton), Australia