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Act by coating the wall of the GI tract and adsorbing bacteria or toxins that cause diarrhea. Includes kaolin and pectin. Activated charcoal, Pepto-Bismol, Kaopectate
Relieve or control the symptoms of acute or chronic diarrhea. Include (1) opiates and opiate related agents, (2) somastatin analogue, (3) adsorbents, and (4) miscellaneous antidiarrheals.
Medications used to stop vomiting. Frequently used to prevent motion sickness, and for side effects of anticancer (antineoplastics) agents, radiation, and toxins
Active ingredients in marijuana, were approved for clinical use in 1985 to alleviate nausea and vomiting resulting from cancer treatment.
Used to eliminate fecal matter. Results in a soft to watery stool with some cramping. Dosage determines whether it is a laxative or a cathartic
chemoreceptor trigger zone (CTZ)
Lies near the medulla and is the area of the brain that is involved in the sensation of nausea and the action of vomiting.
Lubricants and stool softeners (surface-acting or wetting drugs) used to prevent constipation. Decreases straining during defecation.
Used to eliminate fecal matter. Promotes a soft stool. Dosage determines whether it is a laxative or a cathartic
selective chloride channel activators
New category of laxatives used to treat idiopathic constipation in adults. Activates chloride channels in the lining of the small intestine, leading to an increase in intestinal fluid secretion and motility.
Cause vomiting when stimulated. Located in the medulla oblongata; recieves and propagates impulses to the upper GI tract organs, diaphragm, and abdominal muscles.
Vomiting - diaphragm & GI
Vomiting Center (VC)
Chemoreceptor trigger zone (CTZ)
Toxic substance ingestion
Antiemetics - Nonpharmacologic measures
Weak tea - dilute with water
Crackers - no butter
Toast - no butter
Ginger Ale, Sierra Mist -room temp, make it flat (shake out bubbles)
Nonprescription antiemetics -Antihistamines
Dimenhydrinate (Dramamine) - Motion sickness
Diphenhydramine (Benadryl) - Allergies
Side effects (similar to anticholinergics)
Constipation - urinary retention
Nonprescription antiemetics - Bismuth subsalicylate (Pepto-Bismol) - for indigestion
Acts directly on gastric mucosa to suppress vomiting
Antiemetics -Prescriptive antihistamines
Hydroxyzine (Vistaril) - anti-hypnotic (has additivie effect w/Benadryl)
- Promethazine (Phenergan) - comes in suppository form
Acts on vomiting center (VC), decreases stimulation of CTZ
Antiemetics - Promethazine (Phenergan)
Inhibit CTZ, blocks H1 receptor sites
dry mouth, blurred vision, tachycardia, constipation, urinary retention, photosensitivity,
- EPS - extrapyramidal syndrome includes:
--- tardive dyskinesia - Involuntary repetitive movement
--- acute dystonia - sudden spasms (face,neck,back, limbs)
--- akathisia - inner restlessness
Antiemetics - Dopamine antagonists
Haloperidol (Haldol) - can be anti-hypnotic -called vitamin H
Blocks dopamine (D2) receptors in CTZ
Metoclopramide (Reglan) works for nausea, open heart or GI surgery - delays gastric emptying
Blocks D2 receptors in CTZ
Sedation, diarrhea, EPS
Antiemetics - Benzodiazepines - suffix -PAMs and -LAMs
Lorazepam (Ativan) - also called "Vitamin A"
Cancer chemotherapy - used as a premed to avoid nausea
Used in combination with a glucocorticoid and serotonin 5-HT3 receptor antagonist
Antiemetics - Serotonin receptor antagonist
Ondansetron (Zofran) - ODT under the tongue
comes in foil package
Blocks serotonin receptors in CTZ and afferent vagal nerve terminals in UGI
Cancer chemotherapy - to pretreat for nausea
Headache, diarrhea, dizziness, fatigue
Antiemetics - Glucocorticoids
Dexamethasone (Decadron) - spinal/cerebral injury
Methylprednisolone (Solu-Medrol) - COPDers
Use: cancer chemotherapy - used as a premed
Antiemetics - Cannabinoids - 1st approved medical marujuana
Store in a refrigerator - Small white oval pill (like a tic-tac)
Drowsiness, dizziness, dry mouth, impaired thinking, euphoria, mood changes, headaches, confusion, depersonalization, nightmares, incoordination, memory lapse, anxiety
Antiemetics - Miscellaneous
Suppress impulses to CTZ
Drowsiness, dry mouth, tachycardia, urine retention, constipation, diarrhea, blurred vision, hypotension, EPS
Antiemetics - Nursing interventions
Provide mouth care
Monitor vital signs, bowel sounds
Monitor for dehydration
Warn not to consume alcohol when taking an antiemetic as it depresses the CNS
Warn pregnant females to avoid antiemetics drug of choice is Zofran ODT with a Pregnancy caregory B
Avoid driving motor vehicles - causes drowsiness
Emetics - Ipecac (OTC)
---- Stimulates CTZ & acts directly on gastric mucosa
---- Induces vomiting after toxic substance
---- Avoid vomiting if substance is caustic or petroleum
---- If vomiting contraindicated, activated charcoal is given
---- Use ipecac syrup, not ipecac fluid extract
---- Take with a glass of water or fluid, not with milk or carbonated beverage
---- Vomiting occurs in 15 to 30 minutes (lavage likely if nothing after 15 minutes)
---- If vomiting does not occur, give activated charcoal (absorbs toxins) - It is black as grill charcoal, clothing warning
---- Gastric lavage may be needed if vomiting does not occur
Diarrhea defined as 3 or more episodes per day
Spicy or spoiled foods
Bacteria (Escherichia coli)
inflammatory bowel disease (IBS)
Antidiarrheals - Opiates - NO MORE than two days
Should not be used for more than 2 days or if fever is present
Opiates and opiate-related agents (NO MORE THAN TWO DAYS)
Antidiarrheals - Opiates and opiate-related agents
Paregoric (camporated opium tincture)
Diphenoxylate with atropine (Lomotil)
Kept in a locked drawer - controlled substance
Opiates decrease GI motility this is why they work
Opiates may cause respiratory depression
Especially children and elderly
May cause physical dependence
Atropine contraindicated in glaucoma
WATCH FOR pernicious anemia
Antidiarrheals - Somatostatin analog
Octreotide (Sandostatin) - used with cancer PTs
Use: for severe diarrhea from cancer
Antidiarrheals - Adsorbents
Bismuth salts (Pepto-Bismol)
Action: coats GI tract, absorbs bacteria or toxins
Antidiarrheals - Nursing interventions
Monitor BP, Respirations
Report more than 10-15 mmHg decrease in BP - HYPOTENSION
Monitor frequency of bowel movements and bowel sounds
Assess for evidence of dehydration
Avoid fried foods, milk, and sedatives
If diarrhea persists after 48 hrs, notify MD
Bowel obstruction, fecal impaction _Good for MS patients
Chronic laxative use, ignoring urge to defecate
Side effect of drugs
Lack of exercise, fiber, water
Laxatives: promote soft stool
Cathartics: soft to watery stool with cramping
Purgatives: watery stool with cramping
Types of laxatives
Emollient (stool softeners)
Undiagnosed abdominal pain
Inflammatory disorders of the GI tract
Appendicitis (9-10 times stool is the cause of appendicitis), diverticulitis, ulcerative colitis
Pregnancy - Benefits outweigh risk when there is a risk of early delivery
Osmotic (Saline) Laxatives
Polyethylene glycol (GoLYTELY) - preps for colonoscopy
Lactulose (Chronulac) - monitor liver failure (cirrhosis)
High ammonia - confusion
Hyperosmolar salts pull water into colon, increase water in feces to increase bulk, which stimulates peristalsis
Fluid and electrolyte imbalances, hypotension, weakness
Stimulant (Irritant) Laxatives
Phenolphthalein (Ex-Lax, Correctol) reddish brown color urine is mistaken for hematuria
Increase peristalsis by irritating sensory nerve endings in intestinal mucosa
Results: orally 6-12 hrs, supp 15-60 min
Abdominal cramps, weakness, reddish brown urine, diarrhea
Bulk-Forming Laxatives - Mix with water or juice
Psyllium hydrophilic mucilloid (Metamucil)
Calcium polycarbophil (Fiber-Con)
Absorb water into intestines, increase bulk and peristalsis
Mix in glass of water or juice, stir, drink immediately, follow with 1 glass water
Nausea,vomiting, gas, diarrhea
Emollients (Stool Softeners)
Lowers surface tension
Promotes water accumulation in intestine
Emulsifies and lubricates feces for easier passage
Reduces straining post surgery or myocardial infarction use with fresh CABG patients, MI, CAD (no vagal)
Abdominal cramping, nausea, vomiting, diarrhea
Q: A client complains of constipation and requires a laxative. The nurse reviews a common cause of constipation which includes?
A: Lack of Exercise
Q: A client has nausea and is taking andansetron (Zofran). The nurse explains that the action of this drug is what?
A: Block seratonin receptors in the CTZ
Q: A client who has constipation is prescribed a bisacodyl suppository. The nurse explains that bisacodyl does what?
A: Acts on smooth intestinal muscle to increase bulk and peristalsis.
Q: A client is using the scopalimine patch to prevent motion sickness. The nurse teaches the client that which is a common side effect of this drug?
A: Dry mouth
Q: When metoclopramide (Reglan) is given for nausea, the client is cautioned to avoid which substance?
Q: The nurse is administering opium tincture (paregoric) to a client. What five items should be included in the teaching regarding this medication?
1. Warn the client to avoid laxative abuse
2. Record the frequency of bowel movements
3. Encourage the client to increase fluid intake
4. Intruct avoiding this drug if the client has narrow angle glaucoma
5. Warn the client against taking sedatives concurrently.
Q: For what three conditions would a laxative be indicated?
A: (1) A young adult female who is postpartum following a vaginal delivery with an episiotomy
(2) A young adult client affected by IBS
(3) An older adult client preparing for a colonoscopy
Q: Children and older adults are usually not administered prochlorperazine (Compazine) for nausea and vomiting due to risk for which effect?
A: Extrapyrimidal symptoms such as restlessness, anxiety, and spasms of the face and neck
Q: Laxatives containing sodium are contraindicated for which of the following client conditions?
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