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Pharm Antibiotics and Antivirals
Antibiotics I ppt, Antibiotics II ppt , Anribiotics III, Antivirals and fungals
Terms in this set (75)
Drug of choice for mycoplasma pneumoniae, Chlamydia (pneumonia, STD, eye infections), rickettsiae (Lyme disease)?
Used for acne, gonorrhea, pertussis, & UTI, inhibits ADH,SIADH?
Used to kill many resistant bacteria (MRSA, VRSA, resistant streptococci, VRE) plus atypicals?
These drugs should not be given IM?
These cross the placenta & bind to calcium in teeth & growing bones causing fluorescence, discoloration and enamel dysplasia, boney deformities?
Don't give in pregnancy or to kids under 8 yo?
Works on Gm + (like pneumococci, streptococci, staphylococci), atypicals (mycoplasma, chlamydia, helicobacter, mycobacterium, Legionella).
NOT good for UTIs and any infection associated with colon, don`t use in meningitis?
Cross resistance complete with all ?
Don`t need to adjust in renal failure and is exposed to fetus ?
Drug of choice in chlamydial infections (eye, lung, genital), a drug of choice in CAP?
If allergic to PCN can use if suspect staph, strep, pneumococci, syphilis or gonorrhea (B/C resistance is a problem not first choice)?
Acute cholestatic hepatitis if take more than one week?
inhibit cytochrome P450, which means it can interact with a number of drugs including: theophylline, warfarin, cyclosporine & digoxin?
Has a new link to arrythmias?
It's a special subgroup of macrolides called ketolide?
Many bugs that are resistant to macrolides are sensitive to?
Used for CAP, acute exacerbation of chronic bronchitis, sinusitis and strep pharyngitis
Unlike other macrolides because it is not involved in P450 system?
Can prolong Q-T interval?
strep, staph, pneumococci, ANAEROBES (gets into abcesses)
Most common cause of superinfection from clostridia difficile , aslo causes rash and neutropenia?
Used for multi drug resistant gm + bacteria infections (Gets VRE and MRSA). A spectrum similar to vancomycin, but also can kill some vancomycin resistant drugs?
Causes thrombocytopenia & neutropenia ?
transported across cell membrane and cause irreversibly inhibition of protein synthesis causing cell death
Can use in meningitis because it can get in if inflamed and synergistic with other antibiotics can also use in endocarditis?
MUST make dose adjustment with kidney failure
Works well for Sepsis and bacteremia
Acts synergistically with vancomycin or penicillin
Used as part of multiple antibiotic regimen for TB?
Ototoxic and Nephrotoxic: increased serum Cr, more if also taking loop diuretics or other renal toxic drugs (vancomycin & amphotericin)
Disrupts DNA helix
Antiprotozoal & good against anaerobes also
anaerobic or mixed abdominal infections, vaginitis (trichinosis and bacterial), drug of choice for C Difficile
ADRs- nausea, diarrhea, stomatitis (oral ulcers), peripheral neuropathy,disulfiram reaction
Penicillins mostly work on what gram ?
For Penicillins the absorption is decreased by what?
Doesn't get into prostate, eye, bone or CNS
Is penicillin teratogenic?
No but does cross the placenta
May need to decrease the dose of penicillin if kidneys are not working well? T or F
Penicillin can be excreted slower with this drug present also?
Which penicillins are not good if something from intestine, or E. coli
V and G
MRSA is resistant to this group of antibiotics.(penicillins)?
Are drugof choice for...Streptococcal infections,Meningococci ,Enterococcus, Treponema pallidum (syphilis), Clostridia (Clostridia diphtheria causes diphtheria & clostridia perfringens causes gas gangrene)?
Penicillin (G and V)
Really only good for killing staph that is NOT MRSA?
Most often used in long term treatment of endocarditis or osteomyelitis or skin or soft tissue infection that has been shown by culture to NOT be MRSA (this does not happen very much in the outpatient setting)
greater activity against gm negative bacteria (gm -) than natural penicillins
Can cause seizures in people with kidney problems?
Can cause hypoprothrombinemia?How do you treat?
cephalosporins , give vitamin K
What drugs get into the CSF and are used to meningitis?
3rd generation cephalosporins , ceftriaxone and cefetaxime
Used for resistant meissaria gonorrhea?
3rd generation cephalosporins
The ultimate gram negative drug need ID approval to use?
Broadest spectrum Beta Lactam Drug?
Used against MRSA?
Causes Red Man`s Syndrome?
Used for VRE?
Cidal drug that only works in urine?
Used for treeatment resistant TB?
Put in the eye for bacterial conjunctivitis and trachoma ?
Used as an antibiotic to prevent infection of burn wounds?
Used for inflammatory (not infectious) bowel disease?
Hemolytic anemiaEspecially if glucose-6-phosphate dehydrogenase deficiency and Aplastic anemia are possible ADRs?
drug of choice for Pneumocystis jiroveci pneumonia?
the drug of choice for anthrax?
Don't use if already have QT prolongation, hypokalemia, or if on antiarrhythmic drug?
Tendonitis and tendon rupture are rare ADRs ?
Most active agent against mycobacterium tuberculi (TB)?
Systemic lupus syndrome (SLE),Hepatitis, and Peripheral neuropathyADRs?
Its is taken PO and is a special drug b/c gets into all phagocytic cells?
Changes colors of body secretions and used in leprosy?
Can cause Retrobulbar neuritis: inflammation of optic nerve with decreased visual acuity & red-green color blindness ?
Broadest of all antifungal agents and given IV only?
Becoming drug of choice for serious or resistant candida infections?
For HSV in eye (keratitis)?
Highly active antiretroviral therapy
This method of treatment is suppressive
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