Inflammatory disease producing vascular compromise of bowel mucosa. More common in premature infants. caused by intestinal ischemia, bacterial or viral infection, and immature gastrointestinal mucosa. Free air = perforation. Distended bowel, dilated bowel loops, and bowel wall thickening. Monitor stools and emesis for occult blood; abdominal girths. Blood cultures, anemia, leukopenia, leukocytosis, thrombocytopenia, electrolyte imbalance, metabolic or respiratory acidosis. Put NPO for 10 days. If perforate - surgical removal of dead gut and colostomy. Can re-anstomose after gained weight. Often supplemented with probiotics. Obliteration of bile ducts (fibrosis), progressive inflammatory process, immune mechanisms or viral injury. management includes Kasai procedure, liver transplant. They are Jaundice for 2-3 weeks after neonatal jaundice resolves. Dark yellow urine. Light-colored, pasty stools or white or tan. Blocked bile flow from liver to duodenum causes inflammation and fibrotic changes in liver. Lack of bile acids interferes with digestion of fat and absorption of fat-soluble vitamins A, D, E, & K. Steatorrhea and nutritional deficiencies. Abdominal pain, hepatomegaly, splenomegaly. Easy bruising, prolonged bleeding time, and intense itching d/t deposits of bilirubin. FTT and malnutrition. Liver biopsy. Hepatomegaly and abd distention. Poor fat metabolism - FTT, poor weight gain. Pruritis. Irritability Chronic inflammation of the liver. Causes include: viruses (EBV, CMV, HIV), chemical reactions, drug reactions, neoplasms, CHF, shock, idiopathic, autoimmune, or metabolic.