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Terms in this set (18)
What is the order of most common to least common blood types?
O > A >> B >>AB
What antibody type makes up the anti-blood antigen antibodies?
Are these antibodies present at birth?
Not present at birth - produced in the first weeks/months of life
For the following blood types, what are the antibodies present?
O, A, B, AB
True or false: Rh/D+ blood is not very common?
False: very common
For blood donation: give the color of the sample each of these:
Which lasts the longest and which lasts the shortest
Shortest = platelets = 5 days
Longest = 1 year: plasma and Cryptoprecipitated AHF
Which of these need to be rerigerated, kept at room temperature or frozen
Whole blood = Refrigerated
Red blood cells = refrigerated
Platelets = kept at room temperature
Plasma = frozen
Cryoprepitated AHF = frozen
What are uses of cryoprecipitatated AHF?
2. Von willebrand disease
3. patients who need fibrionogen
Plasma would be used for? (3)
1. Burn patients
3. Bleeding diroders
What is blood grouping?
Determining the red cell antigens in the blood of a donor and a recipient
What is agglutination?
The clumping of cells in the presence of an antibody
What is cross matching?
Mixing of donor and recipient blood --> cross matching is positive if agglutination occurs when donor and recipient's bloods are incubated together
What are the two purposes of cross matching?
...To ensure what?
1. to ensure that blood grouping is correct
2. To ensure that the recipient has no naturally occuring or active immune response antibodies against the donor cells
Why can transfusion reactions ocassionally occur?
Because the plasma of the donor can have antibodies against the recipient's blood cells, you will occasionally see some agglutination of the recipient cells
What symptoms would you expect to see if there is a transfusion reaction?
1. Rise in ______
2. Renal _____ or an______
1. Rise in blood bilirubin
2. Renal damage or aneuria
What scenario will result in hemolytic disease of the newborn?
Rh- mother, Rh+ father, results in an Rh+ child.
During birth of this child, there is some hemorrhage of the placenta leading to exposure of fetal blood with Rh factor to the maternal blood. Mother develops anti-Rh antibodies
Now if the mother has a second Rh+ baby, the IgG anti-Rh antibodies can now cross the placenta and lyse the fetal blood cells
What is the treatment to prevent hemolytic disease of the newborn?
Treat the mother with anti-D antibodies post partum to "mop up" all the anti-D antibodies
What is autologous transfusion and why do people do it?
Autologous transfusion is when people pre-deposit blood weeks prior to elective surgery, so that after the surgery they can replace lost blood with their own blood
They do this because there is increased worry of blood bourn diseases such as AIDS, Hep B/C
THIS SET IS OFTEN IN FOLDERS WITH...
HIS17 - T cell biology
HIS18 - B cell biology
HIS19 - infection
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