Intro to analgesics and pain
Terms in this set (13)
Nociceptive pain treatment
Analgesic ladder (WHO)
Analgesic ladder is not used for which pains?
Not used for cancer treatment of breakthrough pain
Neurological or neuropathic pain treatment
Antidepressants and anticonvulsants
Psychogenic pain treatment (e.g hypochondria)
Psychopharmaceutical drugs, anxiolytics, antidepressants, antipsychotics, placebo
What is breakthrough pain?
Sudden flare of pain that "breaks through" the long acting medication prescribed to treat moderate to severe persistent pain. Cancer patients prone to this, usually the patients treated with opioids.
Oncological pain- somatic manifestations
Sharp or dull pain
Oncological pain- emotional manifestations
Tissue damage --> production of prostaglandins and other mediators --> effects on the free nerve endings --> transduction of signal up to the brain neurons --> pain interpretation
Mediators of pain
What are some endogenous analgesics?
Which receptors do these endogenous substances bind to?
Alpha2 and NMDA
Which tracts convey pain?
Spinothalamic and spinoreticulothalamic tracts
Which tract conveys sharp and well localized pain?
Spinothalamic (dull and poorly localized is spinoreticulothalamic)