Pass well across HEB Exhibit short but STRONG analgesia (100 more than morphine) But also strong respiratory center depression Can cause muscle rigidity Risk of serotonin syndrome if in combination with 5HTergic drugs
Indications of fentanyl etc
Anaesthesiology - neuroleptoanalgesia (ap+ opioid), analgosedation (bzd + opioid) Therapy of strong pain (AMI, cancer pain) Fentanyl is TTS - breakthrough pain and chronic pains - for breakthrough pain even better is transmucous
Less respiratory depression than morphine Less emetogenic Tolerated parenteral administration
Therapy of strong pain - post surgical, AMI..
Strong opioid prescription requires
Less suppression of respiratory center than morphine But also less analgesic potency than morphine Metabolite is PROCONVULSIVE Hallucinogenic Oral and parenteral