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5 Written questions

5 Matching questions

  1. degree of blood flow in brain/liver/kidneys, skeletal muscles and skin, adipose tissues
  2. cons of oral/enteral administration
  3. sublingual and rectal administration
  4. parenteral administration (a. IV, b. subcutaneous, c. intramuscular, d. intraarterial, e. intrathecal)
  5. absorption
  1. a (sublingual allows drug to bypass intestines and liver preventing first pass metabolism), rectal(only 50 % of drug enters the liver and is metabolism. disadvantages include irregular and incomplete absorption and irritation of the rectal mucosa)
  2. b a. intravenous: aqueous solution injected into a vein, b. subcutaneous: inject below skin in subc tissues, c. intramuscular into muscles, d. intraarterial: rare b/c makes bleed a ton, e. intrathecal: inject into cerebrospinal fluid of spinal subarachnoid space. OVERALL: parenteral have many advantages over oral admin including more rapid extensive and predictable admin, can be given to unconscious patients. disadvantages include necessity for aseptic protocols/pain/difficult self-med.
  3. c brain, liver, kidneys have excellent blood flow, skeletal muscles and skin less, adipose tissues even less.
  4. d rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.
  5. e reduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues

5 Multiple choice questions

  1. area under the curve: overall exposure to drug over time.
  2. atp required. carrier protein assists drug in entering cell
  3. clas I: drugs where the dose is less than albumin's capacity to bind (when administered, there will be excess albumin for further binding). class II:given in doses much greater than albumin's ability to bind to it (means there is much more of the drug left over, causing lots of the drug to be free and not to be bound to albumin). if you combine a class I with a class II, free drugs levels of Class I will be much higher, potentially dangerous and may cause overdose situation. Free drugs are active, bound drugs are inert)
  4. New process
  5. administration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.

5 True/False questions

  1. very hydrophobic drugscan easily get out of blood stream

          

  2. facilitated diffusionphysiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)

          

  3. Enteral administration. a. enteric coated pills, b.controlled release pillsadministration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.

          

  4. distribution.rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.

          

  5. t 1/2minimum trough concentration