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5 Written questions

5 Matching questions

  1. AUC
  2. cons of oral/enteral administration
  3. Enteral administration. a. enteric coated pills, b.controlled release pills
  4. active transport
  5. charge of drug
  1. a atp required. carrier protein assists drug in entering cell
  2. b reduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues
  3. c determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH
  4. d a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
  5. e area under the curve: overall exposure to drug over time.

5 Multiple choice questions

  1. describes action of drugs wihtin body and absorption, [How drugs move in body and how quickly] distrib, metabolism and elimination of drugs in addition to the rate or kinetics at which drug's actions begin and their duration. "ADD ME" (sp?) scheme
  2. 2/3 in intracellular compartment and 1/3 in extracellular compartment (between cells). Drugs can distrib into any of these compartments dep on size and hydrophobicity of drug. (V(d)=Total amt of drug in body/plasma concentration of drug-->Know: small V(d) indicates drug is primarily sequestered in plasma, a Large V(d) indicates that relatively little of the drug stays in plasma (if mroe than one, more disrib in body and less in bloodstream if less than one, less in body and more in bloodstream, if 1-equal)
  3. minimum trough concentration
  4. a. first pass hepatic metabolism: first pass metabolism refers to drugs entering hepatic portal system from intestines, b. drug solubility: very hydrophilic or hydrophobic drugs have difficulty crossing cell membranes and entering most drugs prefer to be hydrophobic and a little hydrophilic so they can pass cell membranes easily., c. chemical instability: some drugs may be affected by stomach's pH or various degradative enzymes in GI tract., d. chemicophysical properties of the drug(suzem salt form)
  5. inhalation, intranasal, topical, transdermal (nicotine patches)

5 True/False questions

  1. passive diffusionphysiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)

          

  2. very hydrophobic drugsdetermine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH

          

  3. protein bindingthe prcoess thru which the drug leaves the bloods tream and enters interstitium (absorption is about intestines, distrib is about bloodstream). 4 aspects: blood flow, capillary permeability, drug structure, degree of binding to proteins

          

  4. degree of blood flow in brain/liver/kidneys, skeletal muscles and skin, adipose tissuesbrain, liver, kidneys have excellent blood flow, skeletal muscles and skin less, adipose tissues even less.

          

  5. sublingual and rectal administrationreduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues