5 Written questions
5 Matching questions
- parenteral administration (a. IV, b. subcutaneous, c. intramuscular, d. intraarterial, e. intrathecal)
- charge of drug
- other routes of admin
- administration of drugs
- a a. intravenous: aqueous solution injected into a vein, b. subcutaneous: inject below skin in subc tissues, c. intramuscular into muscles, d. intraarterial: rare b/c makes bleed a ton, e. intrathecal: inject into cerebrospinal fluid of spinal subarachnoid space. OVERALL: parenteral have many advantages over oral admin including more rapid extensive and predictable admin, can be given to unconscious patients. disadvantages include necessity for aseptic protocols/pain/difficult self-med.
- b inhalation, intranasal, topical, transdermal (nicotine patches)
- c administration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.
- d determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH
- e looks at how drugs act in the body and deals with [At the site of action, what the drug does] mechanisms of action in addition to the actions of different drug concentrations or doses
5 Multiple choice questions
- maximum concentration:
- area under the curve: overall exposure to drug over time.
- a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
- physiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)
- describes action of drugs wihtin body and absorption, [How drugs move in body and how quickly] distrib, metabolism and elimination of drugs in addition to the rate or kinetics at which drug's actions begin and their duration. "ADD ME" (sp?) scheme
5 True/False questions
protein binding → most drugs reversibly bind to plasma proteins. drugs bound to albumin is going to be inactive. albumin is the most common protein in the plasma, albumin keeps blood within the blood vessels. As plasma concentration of the drug increases, more binding occurs.
active transport → atp required. carrier protein assists drug in entering cell
class I vs class II drugs → administration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.
very hydrophobic drugs → can easily get out of blood stream
ADME scheme → absorption, distribution, metabolism and elimination.