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5 Written questions

5 Matching questions

  1. other routes of admin
  2. Cmax
  3. Enteral administration. a. enteric coated pills, b.controlled release pills
  4. C min
  5. AUC
  1. a inhalation, intranasal, topical, transdermal (nicotine patches)
  2. b a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
  3. c maximum concentration:
  4. d area under the curve: overall exposure to drug over time.
  5. e minimum trough concentration

5 Multiple choice questions

  1. reduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues
  2. a. first pass hepatic metabolism: first pass metabolism refers to drugs entering hepatic portal system from intestines, b. drug solubility: very hydrophilic or hydrophobic drugs have difficulty crossing cell membranes and entering most drugs prefer to be hydrophobic and a little hydrophilic so they can pass cell membranes easily., c. chemical instability: some drugs may be affected by stomach's pH or various degradative enzymes in GI tract., d. chemicophysical properties of the drug(suzem salt form)
  3. the prcoess thru which the drug leaves the bloods tream and enters interstitium (absorption is about intestines, distrib is about bloodstream). 4 aspects: blood flow, capillary permeability, drug structure, degree of binding to proteins
  4. New process
  5. physiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)

5 True/False questions

  1. degree of blood flow in brain/liver/kidneys, skeletal muscles and skin, adipose tissuesreduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues

          

  2. sublingual and rectal administrationreduced drug absorption, emesis due to gastrointestinal irritation, destruction of some of drug thru enzymatic degradation and gastric acid, inconsisten absorption, and patient compliance issues

          

  3. t 1/2minimum trough concentration

          

  4. parenteral administration (a. IV, b. subcutaneous, c. intramuscular, d. intraarterial, e. intrathecal)a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration

          

  5. active transportatp required. carrier protein assists drug in entering cell