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5 Written questions

5 Matching questions

  1. C min
  2. facilitated diffusion
  3. charge of drug
  4. protein binding
  5. class I vs class II drugs
  1. a most drugs reversibly bind to plasma proteins. drugs bound to albumin is going to be inactive. albumin is the most common protein in the plasma, albumin keeps blood within the blood vessels. As plasma concentration of the drug increases, more binding occurs.
  2. b no atp. carrier protein assists drug in entering cell
  3. c clas I: drugs where the dose is less than albumin's capacity to bind (when administered, there will be excess albumin for further binding). class II:given in doses much greater than albumin's ability to bind to it (means there is much more of the drug left over, causing lots of the drug to be free and not to be bound to albumin). if you combine a class I with a class II, free drugs levels of Class I will be much higher, potentially dangerous and may cause overdose situation. Free drugs are active, bound drugs are inert)
  4. d minimum trough concentration
  5. e determine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH

5 Multiple choice questions

  1. absorption, distribution, metabolism and elimination.
  2. area under the curve: overall exposure to drug over time.
  3. time for drug concentration to fall by half
  4. (sublingual allows drug to bypass intestines and liver preventing first pass metabolism), rectal(only 50 % of drug enters the liver and is metabolism. disadvantages include irregular and incomplete absorption and irritation of the rectal mucosa)
  5. inhalation, intranasal, topical, transdermal (nicotine patches)

5 True/False questions

  1. pharmacodynamicsdescribes action of drugs wihtin body and absorption, [How drugs move in body and how quickly] distrib, metabolism and elimination of drugs in addition to the rate or kinetics at which drug's actions begin and their duration. "ADD ME" (sp?) scheme

          

  2. passive diffusionno atp. carrier protein assists drug in entering cell

          

  3. distribution.rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.

          

  4. Cmaxminimum trough concentration

          

  5. pharmacokineticsdescribes action of drugs wihtin body and absorption, [How drugs move in body and how quickly] distrib, metabolism and elimination of drugs in addition to the rate or kinetics at which drug's actions begin and their duration. "ADD ME" (sp?) scheme