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5 Written questions

5 Matching questions

  1. passive diffusion
  2. sublingual and rectal administration
  3. administration of drugs
  4. absorption
  5. Enteral administration. a. enteric coated pills, b.controlled release pills
  1. a (sublingual allows drug to bypass intestines and liver preventing first pass metabolism), rectal(only 50 % of drug enters the liver and is metabolism. disadvantages include irregular and incomplete absorption and irritation of the rectal mucosa)
  2. b administration routes of drugs play large role in drug absorption, 2 major mehtods: a) enteral means thru gastroint tract. b)parenteral: entrance outside of GI tract, usually via injection.
  3. c rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.
  4. d a)enteric coated allows drug to pass thru stomach without being destroyed by gastric acid. b)controlled release preparation allows drug to release a uniform stream to absorption site over relatively long period of time (disadvantages of this include differences between patients, failure of controlled release causing dose dumping or reduced drug release)other forms of enteral administration
  5. e physiochemical makeup helps determine how easy or difficult drug passes thru membranes (concentration gradient, how lipophilic and surface area of cell)

5 Multiple choice questions

  1. area under the curve: overall exposure to drug over time.
  2. time for drug concentration to fall by half
  3. maximum concentration:
  4. most drugs reversibly bind to plasma proteins. drugs bound to albumin is going to be inactive. albumin is the most common protein in the plasma, albumin keeps blood within the blood vessels. As plasma concentration of the drug increases, more binding occurs.
  5. minimum trough concentration

5 True/False questions

  1. distribution.rate and extent that the drugs leaves site of administration. a)how long it takes for an oral drug to enter bloodstream from small intestine and how much of the drug makes it. b. bioavailability: [how much of a drug makes it into the bloodstream] what fraction of the dose of a drug reaches its site of actino or a body fluid where the drug has accss to its action.

          

  2. active transportatp required. carrier protein assists drug in entering cell

          

  3. Factors that affect bioavailabilityno atp. carrier protein assists drug in entering cell

          

  4. charge of drugdetermine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH

          

  5. very hydrophobic drugsdetermine how readily crosses membrane. uncharged chemicals more easily pass membranes. weak acids and bases can be charged or uncharged, but each drug's charge changes based on interaction with body's pH