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RBC with small, uniform spines surrounding cell
Most common cause of formation is an in-vitro artifact which is called crenation.
lack of central pallor, smaller than normal. More likely seen in dogs, reduced membrane- macrophage destruction. Immune mediated disease, Hemolytic anemia, transfusion with rejection
round inclusions from disruption in hemoglobin. May be seen in cats normally. Stain blue
onion or garlic
a dead cell in which the outline remains visible, but whose nucleus and cytoplasmic structures are not stainable. A red blood cell after loss of its hemoglobin
some of the irregular shapes appear as helmet cells. Fragments of RBC's, indicative of intravascular hemolysis- mechanical damage to RBC's in circulation. Finding is typical in DIC
organized stacking or chains of RBC's, normal in equine, suggests inflammatory disease in other species
Greater than 4-5 segments, aged neutorphil, often seen in chronic infections, V-B-12 deficiency (Giant Schnauzer)
evenly spaced crenation, non-specific disease, rattlesnake envenomation, blood transfusion
spur cells. resemble creanated cells. have multiple irregularly spaced rounded or clublike projections over entire surface of cell. result from alterations in cell membrane, often seen with kidney or liver disease, hemangiosarcoma, DIC, GN
uniconcave erythrocytes with mouth like clear area near cell center; a few in a blood smear are insignificant; hereditary in some breeds (alaskan malamutes, schnauzers)
Fractured or fragmented RBC. microangiopathy, DIC, iron deficiency, liver disease, heart failure, GN, hemangiosarcoma
intact or ruptured vesicles on edge of RBC, seen in iron deficiency anemia, liver disease
Sphere spaed, lack central pallor. IMHA, zinc toxicity, blood parasites, bee sting, snake envenomation, transfsion
leptocytes, target cells
Cells with less volume and are 'flattened out.' Folded cell has transverse fold. Target cell looks like a target. Both are associated with chronic anemia, liver disease,dyserythropoiesis
Shifting of Hb to one side of the cell, resulting in a clear zone outlined by membrane; oxidant injury: onions, tylenol, vitamin K
"nose" of Denatured Hemoglobin, stains well with New Methylene Blue stain, Can be seen in cats, Can lead to anemia. diabetes, hyperthyroidism, lymphoma, or normal
oval shaped, hereditary in dogs, myelofibrosis, MDS, cats with bone marrow disease, hepatic lipidosis
tear drop shaped. results from failure of the cell to resume its normal shape after passage thru capillaries. Or, can also be an artifact of smear preparation. Tails same direction= artifact of staining. tails opposite direction= myelofibrosis.
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