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USMLE Pharm Antimetabolite Toxicities
Myelosuppression, which is reversibely with leucovorin (folinic acid).
Macrovesicular fatty change in liver, mucositis, teratogenic
Myelosuppression, which is not reversible with leucovorin.
Overdose rescue with thymidine
Bone marrow, GI, liver. Metabolized by xanthine oxidase: increased toxicity with allopurinol
Bone marrow suppression, liver. Can be given with allopurinol.
Leukopenia, thrombocytopenia, megaloblastic anemia