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8 terms

USMLE Pharm Antimetabolite Toxicities

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Methotrexate
Myelosuppression, which is reversibely with leucovorin (folinic acid).
Methotrexate
Macrovesicular fatty change in liver, mucositis, teratogenic
5-FU
Myelosuppression, which is not reversible with leucovorin.
5-FU
Photosensitivity
5-FU
Overdose rescue with thymidine
6-MP
Bone marrow, GI, liver. Metabolized by xanthine oxidase: increased toxicity with allopurinol
6-TG
Bone marrow suppression, liver. Can be given with allopurinol.
Cytarabine (ara-C)
Leukopenia, thrombocytopenia, megaloblastic anemia