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normocytic normochromic anemia
Terms in this set (32)
what are the types of non hemolytic, normocytic anemia
anemia of chronic disease, aplastic anemia, chronic kidney disease
what causes anemia of chronic disease?
inflammation --> inc hepcidin --> dec release of iron from macrophages
what is hepcidin?
binds ferroportin on intestinal mucosal cells and macrophages --> inhibiting iron transport
what are the findings of anemia of chronic disease
dec iron and TIBC, inc ferritin
what causes aplastic anemia
failure or destruction of myeloid stem cells due to radiation, drugs, viral agents, fanconi, acute hepatitis
what are the findings in aplastic anemia
pancytopenia, normal cell morphology, hypocellular bone marrow with fatty infiltration
what are the symptoms of aplastic anemia?
fatigue, malaise, pallor, purpura, mucosal bleeding, petechiae, infection
what are the labs with chronic kidney disease?
dec EPO dec hematopoeisis
what are teh types of extravascular hemolytic normocytic anemia?
hereditary spherocytosis, pyruvate kinase deficiency, HbC defect, sickle cell anemia
what are teh types of intravascular hemolytic normocytic anemia?
G6PD def, PNH
what proteins are deficient in hereditary spherocytosis?
ankyrin and spectrin
what do the cells in hereditary spherocytosis look like?
small, round, no central pallor
what do the labs look like with hereditary spherocytosis?
inc MCHC, inc RDW, +osmotic fragility test, - direct coombs test
what are teh symptoms assoc with hereditary spherocytosis?
splenomegaly, aplastic crisis, jaundice, pigmented gallstones
what causes the hemolysis in G6PD?
oxidant stress due to sulfa drugs, fava beans
dec in what protein leads to RBC susceptibility in g6pd?
what are the symptoms of g6pd def?
back pain, hemoglobinuria
what causes hemolytic anemia in a newbord?
pyruvate kinase def
what is the pathogenesis of hemolysis in pyruvate kinase def
dec pyruvate kinase --> dec ATP --> rigid RBC --> swell
what is teh defect in HbC?
glutamic acid to lysine mutation
what causes PNH?
complement mediated RBC lysis due to acquired mutation in hematopoetic stem cell?
what is the triad of PNH?
hemolytic anemia, pancytopenia, venous thrombosis
what are the labs assoc with PNH?
no CD55/59 on RBCs, + ham's test
what mutation causes sickle cell anemia?
substitution of glutamic acid for valine at position 6
what is the pathogenesis of sickle cell anemia?
low o2 --> sickling --> anemia
what are he complications of sickle cell anemia?
aplastic crisis, autosplenectom, splenic sequestration, salmonella osteomyelitis, vaso-occlusive crisis, renal papillary necrosis
what are the treatments for sickle cell disease?
hydroxyurea and bone marrow transplantation
what diseases/drugs causes warm agglutination?
SLE, CLL, methyldopa
what disease/drugs cause cold agglutinin?
cold, CLL, mycoplasma pneumonia, mono
what is a direct coombs test?
anti-Ig Ab causes Rb to agglutinate if covered with Ag
what is indirect coombs test?
normal RBCs agglutinate if serum has anti-RBC surface Ig
what infections cause destruction of RBC?
THIS SET IS OFTEN IN FOLDERS WITH...
Anemia of Chronic Disease & Hemolytic An…
Hematology Ch 9 + 10: IDA & ACD/AOI
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