Disorder caused by alteration in chromosome number (sex chromosome). Found in females. Results from loss of all (monosomy) or part of the sex chromosome X. Clinical manifestations include: Short stature, gonadal failure, short fingers, short neck, cleft palate, cardiac and kidney abnormalities, hearing loss, webbed neck, low hairline, lymphatic obstruction, reproductive defects. Deafness, osteoporosis, hypothyroidism in adult women.