Upgrade to remove ads
Chapter 21: Immunological Surveillance -
Terms in this set (27)
Constantly monitors normal tissues with natural killer cells
What is the function of immunological surveillance?
Identifies and attaches to abnormal cell (non selective) without "self" cell surface protein markers, antibody coating target cell, or with abnormal markers
What is the identification function of NK cells?
Induces apoptosis in cancer cells, foreign and virus infected cells
What is the induction function of NK?
Secretes potent chemicals that enhance inflammatory response
What is the secretory function of NK cells?
Proteins (cytokines) released by activated lymphocytes, macrophages, and virus infected cells
What are interferons?
Chemical messengers released by tissue cells to coordinate local activities
What are Cytokines/what is there function?
Can trigger production of antiviral proteins in surrounding normal cells
What can Cytokines trigger the production of?
Do not kill viruses, but block replication in cell
What is the function of Antiviral proteins?
Alpha and Beta Interferons, Gamma interferons, cytokines
What are the three types of interferons?
Produced by leukocytes, and attract and s stimulate NK cells
What produce alpha and beta interferons/what is there function?
Secreted by T cells and NK cells - widespread immune mobilizing effects, stimulate macrophage activity
What produce gamma interferons/what is their function?
Used to treat Hep C, genital warts, multiple sclerosis, and hairy cell leukemia
What are artificial IFN's used to treat?
Contains 20 special complement (C) proteins
What type of proteins does plasma contain?
Complement antibody action, major mechanism for destroying foreign substances
What is the function of complement proteins?
Include C1-C9, factors B, D, and P, and regulatory proteins
What are included in complement proteins?
Enhances both innate and adaptive defense
What defenses does complement activation enhance?
Classical pathway, alternative pathway, lectin pathway
What three pathways activate the complement system to activate complement proteins?
Fast method, C1 binds to or is fixed to antibody molecule attached to antigen
What is the classical pathway?
Acts as enzyme that catalyzes chain reaction between other C proteins
What does the bound/fixed protein act as?
Slow method (no antibody involved), involves exposure to antigen on surface of a microbe
What is the alternative pathway?
Factor P, factor B, and factor D interact in plasma
What antigens is the alternative pathway exposed to?
Slow method (no antibody involved) - after digesting microbes, macrophages release substances that cause the liver to produce lectins
What is the lectin pathway?
Lectin binds to microbes, causing the activation of C3
What does Lectin do?
End with conversion of inactive complement protein (C3) to active form (C3a + C3b)
What do all three activation pathways end with?
Stimulation of inflammation (histamine release), promoting chemotaxis, opsonization, destruction of target cell membranes
What are the 4 effects of complement activation?
Enhancement of phagocytosis by complements working with antibodies to coat pathogens and make it easier for macrophages to bind
How does opsonization enhance phagocytosis?
5 complement proteins join to form membrane attack complex
How does complement activation destroy target cell membranes?
This set is often in folders with...
4. Blood supply of abdomen
Anatomy- Pathways Guided Reading
Physiology: Post-lab Quiz for Simulating Dialysis…
EXAM 1: LAB #1
You might also like...
A&P 2 Test 3 Connect & worksheet answers
Chapter 20 lecture (immune system)
Chapter 27: Adaptive Immunity
Other sets by this creator
Chapter 11: Nuclear chemistry
Chapter 10: Acids and Bases
Chapter 9: Solutions
Chapter 8: Gases, liquids, and solids
Other Quizlet sets
Unit 2 PHM 350
Day 12 Audition and Motor Development
Chemistry Test 1