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Compilation of all three study guides for this weeks test!

What are maternal factors that are related to the health of the fetus and the outcomes of pregnancy?

Maternal age
Prior maternal disease
Maternal drug use
Maternal birth history

What technique would you recommend to assess the state of pulmonary maturity before birth?


Temporary drops in the fetal heart rate during uterine contractions are known as?


Late decelerations are consistent with what conditions?

Uteroplacental insufficiency and umbilical cord compression

What pH value is associated with fetal asphyxia?


What method is useful in determining gestational age of a newborn?


What is the weight percentile of an infant receiving neonatal intensive care with the designation "preterm AGA"

The infants weight falls between the 10th and 90th percentile.

Tachypnea in the newborn is defined as a respiratory rate greater than what level?


What should you suspect when observing a "bounding" peripheral pulse on a newborn infant?

PDA-patent ductus ateriosus

What conclusion is consistent with the observation of paradoxical breathing?

WoB-Work of breathing is increased

What conclusion could be reached from observations of drawing (reactions) of chest-wall muscle and tissue between the ribs, and above/below the sternum, all occuring during inspiration?

Lung compliance (CL) is decreased

What is the normal arterial PO2 in healthy infants?

>60 mm Hg

What is the relationship between oxygen toxicity and growing lungs versus adult lungs?

Growing lungs are more sensitive to oxygen toxicity than the adult lung

The most probably explanation for the "flip-flop" phenomenon in the newborn is?

reactive pulmonary vasoconstriction

What O2 device would you recommend for a toddler needing a low FIO2?


What conditions may bronchial hygiene therapy be considered for infants or children?

Foreign body aspiration
cystic fibrosis
bronchopulmonar dysplasia (BPD)

What ETT size would be appropriate when intubating a 4-year old child?


What vacuum seting would you use to perform nasopharyngeal or nasotracheal suctioning of a 5-year old child?

-80 to -100 mm Hg

What FIO2 should be used in neonates prior to endotracheal suctioning?

FIO2 10% to 15% higher than FIO2 set in the ventilator

During resuscitation of a newborn, after 15 to 30 seconds of positive-pressure ventilation what should the clinician do?

Evaluate the heart rate

What are signs of infant respiratory distress that indicate a potential need for continuous positive airway pressure (CPAP)?

radiograph indicating hyaline membrane disease or respiratory distress syndrome
Severe retractions

What is considered a limitation of the high-flow nasal cannula?

The amount of airway positive pressure cannot be measured

What VT range should be used for mechanical ventilation of a neonate?

5 to 7 ml/kg

What initial inspiratory time range would you suggest for a term newborn infant being placed on time-cycled, pressure-limited ventilation?

0.25 to 0.30 second

What mean airway pressure is considered potentially deleterious when applying posiive airway pressure?

15 cm H2O

What PEEP level is commonly used in pediatric patients during mechanical ventilation?

5 to 8 cm H2O

In high-frequency ventilation (HFV), CO2 elimination depends mainly on which of the following?

pressure amplituted

What may indicate a decrease in systemic vascular bloodflow during high-frequency ventilation?

Decreased mean arterial pressure (MAP)

What physiologic effect does inhaled nitric oxide have on the lung?

pulmonary vasodilation

What is recommended dose of inhaled NO?

20 parts per million (ppm)

What is not a common indication for ECMO

Persistent pulmonary hypertension of the newborn (PPHN)

What is NOT an inclusion criterion for neonatal ECMO?

gestational age LESS than 35 weeks

What VT range would your recommend for an infant with severe ARDS?

4-5 ml/kg

What does not affect blacental blood flow during pregnancy?

Smoking abstinence

What is a normal blood pressure for a 750 g neonate?


Another name for respiratory distress syndrome (RDS) is?

Hyaline membrane disease

What are the major factors in the pathophysiology of RDS?

Qualitative surfactant deficiency
Increased small airways compliance
presence of the ductus arteriosus

What factor is associated with an increase in the incidence of RDS?

Maternal diabetes

In preterm infants, adequate amounts of surfactant are present... what complication makes the surfactant unusable?

They are trapped in type II cells

What is the first clinical sign of RDS?


What clinical sign is not consistent with the onset of RDS?


What diagnostic parameter is most often used to confirm the diagnosis of RDS?

Chest Radiograph

What finding on a CXR is not typical for RDS?

Hyperinflation-this indicates broncho pulmonary dysplasia

What treatment is the least useful for the treatment of RDS?

Bronchial hygiene techniques

What should be done when a infant utilizing a nasal CPAP deteriorates suddenly into severe hypoxemia on an FIO2 of 60%?

Intubate the infant and begin mechanical ventilation

What is the maximum PIP that should be used with mechanical ventilation of larger premature infants to prevent volutrauma?

30 cm H2O

What is the current standard of care for infants with RDS?

Surfactant replacement

Rescue surcanctant administration is indicated for what types of infants?

Infants diagnosed with RDS

What is believed to be the cause of transient tachypnea of the newborn (TTN)?

delayed clearance of fetal lung fluid

What complication is common in most prematurely born infants?

Transient Tachypnea

What is common in mothers of infants with transient tachypnea?

They tend to have longer labor intervals and a higher incidence of failure to progress in labor

What radiographic finding is common in infants with transient tachypnea?


What treatment usually causes improvement in the initial treatment of transient tachypnea of the newborn

oxygen with low FIO2

What treatment is indicated for infants with transient tachypnea requiring higher FIO2?


What treatment may improve lung fluid clearance in the infant with transient tachypnea?

Frequent turning of the infant

What are basic characteristics of TTN?

Have similar clinical sighs of neonatal pneumonia
There is a rare need for mechanical ventilation
Small chance of persistent pulmonary hypertension
IV administration of antibiotics should be considered

At what gestational age is meconium-stained amniotic fluid common?

GREATER than 37 weeks

When is meconium passed by the infant?

NORMALLY after birth

What percentage of births will present with meconium-stained amniotic fluid?


What is NOT a problem with the typical case of meconium aspiration syndrome?


What is associated with ball-valve obstruction in meconium aspiration syndrome?


What clinical finding is NOT usually seen in meconium aspiration syndrome?

Respiratory alkalosis

What blood gas alteration is usually seen in meconium aspiration syndrome?

hypoxemia and mixed respiratory and metabolic acidosis

What should be done early in the treatment of the non-vigorous infant with meconium aspiration syndrome?


What vent modes are associated with a lesser rate of air leak in MAS?


What has been implicated in the origin of pronchopulmonary pysplasia (BPD)

oxygen toxicity
mechanical ventilation

What factor is NOT associated with the new description of BPD?

Use of HFV

What clinical finding is typically seen with BPD infants?

Hypoxemia and hypercapnia

What is the best strategy in management of BPD?


What therapy has little effect on long-term outcome such as mortality and duration of O2 therapy in infants with BPD?


What is NOT associated with apnea episodes in prematue infants?

Apnea lasts longer than minute

What is NOT associated with causing apnea in premature infants?


Treatment of premature infants with apnea includes?

Tactile stimulation
Bronchial hygiene

What physiologic abnormalit is believed to be the cause of persistent pulmonary hypertension in the newborn (PPHN)?

High pulmonary vascular resistance

What is the NORMAL PVR/SVR ration in the fetus

PVR/SVR ration is greater than 1

What are fundamental pathophysiologic events that explain PPHN?

Vascular spasm
increased muscle wall thickness
decreased cross-sectional area

What factors may stimulate pulmonary vascular spasm and cause persisent pulmonary hypertension in the newborn


What is common in infants with persistent pulmonary hypertension?

Hypoxemia out of proportion to the lung disease detected by radiography

Treatment of the infant with persistent pulmonary hypertension does NOT include


What is an example of an internal obstruction to the infant's airway?


What is the most common type of esophageal atresia?

esophageal atresia with a distal fistula

The pathophysiologic abnormalities associated with congenital diaphragmatic hernia does NOT include

malformation of the left ventricle

Clinical findings associated with congenital diaphragmatic hernia includes?

severe cyanosis
decreased breath sounds
displaced heart sounds

What diagnostic tool serves to confirm the diognosis of CDH?

Chest radiograph

What is the mortality rate for infants with conenital diaphragmatic hernia?

Mortality rate is usually HIGH

What is the most common defect of the abdominal wall?


What are common neuromuscular defects that affect infants?

Spinal muscular atrophy
congenital myasthenia gravis
myotic dystrophy

What is NOT associate with tetralogy of Fallot?

Right ventricular hypoplasia

What are children with tetralogy of Fallot at risk of?

Sudden death from arrhythmia later in life

What is the most likely diagnosis in the newborn with severe cyanosis at birth?

Transposition of the great vessels

What is NOT true regarding ventricular septal defects in infants?

usually cause right-to-left shunting

How soon after birth does the ductus typically close?

5 to 7 days

In left ventricular outflow obstructions, what does systemic blood flow depend on?

The patency of the ductus ateriosus

What is true about infants with hypoplastic left heart syndrome?

They need to be supported with mechanical ventilation

In what defect is heart transplantation an accepted option for treatment.

Hypoplastic left heart syndrome

What is the most common cause of death in infants under the age of 1 year?

Sudden infant death syndrome (SIDS)

What is NOT a maternal characteristic associated with an increased frequency of SIDS?

history of asthma

What infant characteristic is associated with an increased risk of SIDS?

Preterm birth

What is death from SIDS commonly confused with?

Intentional suffocation due to its difficulty to differentiate the characteristics

According to the American Academy of Pediatrics what sleepling position should an infant be placed in?

Supine or side-lying position for the first 6 months

What finding is NOT associeated with gastroesophageal reflux disease (the GERD)?


What criteria is used to diagnose GERD?

esophageal pH testing
upper GI contrast studies
gastric scintiscanning

What kind of orgasm causes bronchiolitis?

Viral organisms

What disease is NOT commonly associated with bronchiolitis most likely to result in respiratory failure?


What finding is NOT typical for infants with bronchiolitis?


What groups of infants should receive passive immunization for RSV?

Chronic lung disease
Infants born less than 32 weeks gestational age
Infants with congenital heart disease

What therapy is considered controversial in the management of infant with severe bronchiolitis?

Bronchodilator therapy

What are characteristics of croup?

Caused by viral organism
Most common form of airway obstruction in children aged 6 months to 6 years
Causes subglottic swelling and obstruction
Most often caused by parainfluenza virus

What is the most common radiographic finding that suggests the presence of croup?

Steeple Sign

What clinical findings suggests the child with croup should be hospitalized?

Stridor at rest
suprasternal reactions
cyanosis on room air
harsh breath sounds

What treatment is LEAST likely to be needed in the treatment of he child with croup?

Mechanical ventilation

What modality is believed to be the cause of a decrease in the reported incidence of epiglottitis over the past decade?


What clinical finding is NOT typically seen in patients with epiglottitis?

Croupy barking cough

What is the most common radiographic finding that suggests the presence of epiglottitis?

Thumb Sign

What therapy is the LEAST likely to be needed in the child with epiglottitis?


What are common complications in patients with cystic fibrosis?

trouble with digestion of fats
Fat-soulable vitamin deficiency

What is the leading cause of death among patients with cystic fibrosis?

lung disease

What test is commonly used to confirm the diagnosis of cystic fibrosis?

sweat chloride

What therapy has been shown to reduce the incidence of bronchiectatic exacerbations in the patient with cystic fibrosis?

inhaled tobramycin

What therapy has been shown to reduce the rate of loss of lung function in patients with cystic fibrosis?

high doses of ibuprofen

What parameter is not considered accurated enough to treat a patient when analyzing CAP gasses?


The time to switcha a patient from CPAP to mechanical ventilation is indicated by?

CPAP of 8-10 cm with a PaO2 of less than 50 torr.
FiO2>80% resulting in a PaO2 of less than 50 torr.

what happens if you increase the PEEP without increasing the inspiratory pressure by the same amount?

Tidal volume will decrease

What are the intervals to perform APGAR tests?

one and five minutes

Fetal lung maturity is indicated when the licithin:sphingomyelin ratio is?


Persistent fetal circulation is represented by the presence of?

patent foramen ovale
patent ductus ateriosus

The effect of the expiratory grunt in a newborn who is in respiratory distress would be to?

prevent atelectasis

The normal respiratory rate in the neonate is?

30 to 60 breaths per minute

Bronchopulmonary Dysplasia (BPD) is frequently caused by?

High FiO2 and high positive pressures

In the fetal heart the foramen ovale allows blood to flow from?

The right atrium to left atrium

What are common characteristics of croup?

affects children under the age of 6
inspiratory and expiratory stridor are common
presence of a harsh, barking cough

What are common characteristics of meconium aspiration syndrome?

Fetal asphyxia precedes aspiration
gasping respiratory efforts by fetus
post-birth, successive intubations and suctioning are required

What is NOT a contraindication for CPAP?


In most newborns the recommended tidal volume via ventilator is?

5-7 ml/kg

When using high frequency ventilation in the neonate the parameter that will increase tidal volume is?

amplitude or driving pressure

What ETT would you use to intubate an infat of 1050 grams?

Size 3.0

What are the effects of CPAP?

improves FRC
Decreases the amount of shunt
reduces the A-a gradient

APGAR score for: body pink, extremities blue equals how many points

APGAR score of 1

Mechanical ventilation of the neonate includes what?

using tidal volumes of 5-7 ml/kg
using I times of 0.3 to 0.7 seconds
using PIPs less than 30 cmH2O

What type of laryngoscope blade is used for intubating neonates?


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