strep throat, wound infections, impetigo, flesh eating: necrotizing fasciitis.
Invades skin to fascia layer below hypodermis and may through exotoxin protease to begin destroying muscle layer attached to the fascia.
Protease, Hyaluronidase, Fibronectin binding protein, etc.
Toxins break down tissue, enter blood, may cause systemic shock.
Usu. Patient has some debilitation to become susceptible to this organism/disease: diabetes, cancer, AIDS, lowered immunity...