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USMLE Immunology First Aid
A set of questions to review Immunology for the Step 1 exam.
Terms in this set (52)
This part of the lymph node is underdeveloped in patients with DiGeorge syndrome. T cells occupy this portion.
What is the site of B cell proliferation within the lymph node?
Splenic dysfunction is associated with the invasion of wich organisms?
SHiN SKiS (Salmonella, Haemophilus influenzae type B, N. meningiditis, S. pneumoniae, Klebsiella, Group B Strep)
What are the kind of cells found in patients postsplenectomy?
Target cells, Howell-Jolly bodies
What is the embryologic origin of the thymus?
3rd branchial pouches
Wich are the HLA types associated with MHC I?
HLA-A, HLA-B, HLA-C
Wich are the HLA types associated with MHC II?
HLA-DP, HLA-DQ, HLA-DR
What disease is associated with HLA-A3?
Wich deseases are associated with HLA-B27?
Rheumatoid Arthritis, Psoriasis, Ankylosing spondylitis, Inflammatory Bowel Disease, Reiter's syndrome
Wich diseases are associated with HLA-DR2?
Multiple sclerosis, hay fever, SLE, Goodpasture's
Wich diseases are associated with HLA-DR3?
Diabetes mellitus type I, Grave's diseases
Wich diseases are associated with HLA-DR4?
Rheumatoid arthritis, Diabetes mellitus type I
Wich diseases are associated with HLA-DR5?
Pernicious anemia, Hashimoto's thyroditis
The process in wich T cells expressing T-Cell Receptors capable of binding surface self MHC molecules survive, is called:
The process in wich T cells expressing T-Cell Receptors with high affinity for self antigens undergo apoptosis is called:
The cell surface markers that function as co-stimulatory signals between the T CD4+ cell and the APC are:
B7 and CD28
What are the contents of the granules released by Cytotoxic T cells in response to virus-infected, neoplastic or donor graft cells?
Perforin, Granzyme, Granulysin
This portion of the antibody structure determines the isotype (IgM, IgD, etc):
Fc (constant region)
What are the forms in wich antibodies act against organisms?
Opsonization, Neutralization and Complement activation
This immunoglobulin isotype crosses the placenta and is the most abundant Ig in blood.
This immunoglobulin isotype can be found as a monomer or dimer, it is found in secretions such as tears, saliva, mucus and breast milk.
This immunoglobulin isotype is produce in the inmediate response to an antigen. It can be either a monomer or a pentamer and it fixes complement but does not cross the placenta.
This immunoglobulin isotype is related to mast cells, basophils and eosinophils. It mediates type I hypersensitivity
What is the difference between Thymus-independent antigens and Thymus-dependent antigens?
Thymus-independent antigens lack a peptide component and therefore cannot be presented by MHC to T cells (lipopolysaccharide from cell envelope of gram-negative bacteria) and they only induce IgM. Thymus-depent antigens contain a protein component and they induce class-switching and form immunologic memory
Wich are the complement proteins associated with anaphylaxis?
What is the function of C3b?
Binds bacteria (Opsonization)
What is the complement protein associated with neutrophil chemotaxis?
Wich complement proteins form the Membrane Attack Complex (MAC)?
Hereditary angioedema is caused by:
Deficiency of C1 esterase
Severe, recurrent pyogenic sinus and respiratory tract infections; increased susceptibility to type III hypersensitivity reactions are dure to:
Deficiency of C3
Neisseria bacteremia can be caused by a deficiency of wich complement proteins?
Paroxysmal nocturnal hemoglobinuria (PNH) is caused by a deficiency of:
What are the functions of IL-1 and IL-6?
Endogenous pyrogens. Causes fever and acute inflamation
What is the function of IL-8?
Major chemotactic factor for neutrophils
What is the function of IL-12?
Induces differentiation of T cells into Th1 cells.
This cytokine mediates septic shock and activates endothelium:
What is the cytokine that activates macrophages?
What is the function of IL-4?
Induces differentiation of T cells into Th2 cells. Enhaces class swtiching to IgE and IgG
This cytokine promotes differentation of B cells. It enhaces class switching to IgA. It also stimulates the growth and differentiation of eosinophils.
What is the function of IL-10?
Inhibits actions of activated T cells.
What is the function of alpha and beta interferons?
Inhibit viral protein synthesis
How does interferon-y act to interfere with viruses?
Increases MHC I and II expression and antigen presentation in all cells.
Epstein-Barr virus is associated with wich B cell surface protein?
The process in wich self-reactive T cells become nonreactive without costimulatory molecule is known as:
What is the difference between Active and Passive immunity?
Active immunity is induced after exposure to foreign antigens, has a slow onset and creates memory. Passive immunity is based on receiving preformed antibodies from another host, has a rapid onset and doesn't create memory
Measles, Mumps, Rubella and Polio (Sabin) are examples of what kind of vaccine?
Polio (Salk), Hep B, Cholera, Rabies
Killed or inactivated
Anaphylatic and atopic; free antigen cross-links IgE on presensitized mast cells and basophils, triggering release of vasoactive amines that act on postcapillary venules.
Type I hypersensitivity
Antibody mediated; IgM, IgG bind to fixed antigen on enemy cell. It is tested for using direct and indirect Coombs.
Type II hypersensitivity
Immune complex formation. Serum sickness and Arthus reaction are examples of it.
Type III hypersensitivity
What is the clinical presentation of Serum Sickness?
Fever, arthralgia, urticaria, proteinuria, lumphadenopathy, 5-10 days after antigen exposure.
Delayed (T-cell mediated) type; sensitized T lymphocytes encounter antigen and then release lymphokines..
Type IV hypersensitivity
THIS SET IS OFTEN IN FOLDERS WITH...
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