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Characteristics of Antigens and Immunogens
Terms in this set (31)
Can bind to mediators of the immune response such as antibodies or T cell receptors
Any substance that is capable of initiating an immune response
Molecule that binds with preformed products of the immune response (antibodies or T cells receptors), but may or may not be immunogenic
Smallest portion of an Ag that is capable of binding an antibody or T cell receptor- also called the "antigenic determinant"
_________________ refers to a substance that is administered with an immunogenicity that non-specifically enhances the immune response to that immunogen.
_________________ prevents dispersion and dilution resulting in slow continuous release and increases the immunologic half-life
Alum (aluminum hydroxide or aluminum phosphate)
_____________________ causes protein immunogenicity to precipitate?
*In Europe, the flu vaccines contain this (squalene)
large nucleic acids
What makes a good immunogen?
What makes a poor immunogen?
charge and shape
What has little to no influence on immunogenicity?
size and complexity
What is directly proportional to immunogenicity?
What is the minimum size requirement for immunogenicity?
Small molecule which alone is not immunogenic, but when conjugated to a larger more complex molecule induces and immune response
Dinitrophenyl conjugated to BSA
What is an example of a Hapten?
An antigen that contains one epitope is called?
Carbohydrate polymers (or homopolymers)
An antigen that contains many identical epitopes are called?
An antigen that contains many epitopes of different specificities are called?
What are some host factors that can effect the persistence of antigens?
-genetics (host immune response genes & herd immunity)
-immunization protocol (route, dose, use of adjuvants, timing, # of injections)
-Persistence of the antigen
-Age/nutritional status/stress/overall health
What are some factors that can immunogenicity?
Any substance which nonspecifically activates lymphocytes resulting in the production of products such as antibodies (B lymphocytes
) or cytokines (T lymphocytes) is called?
A large complex protein
Which of the following molecules is most likely to initiate an immune response?
1. A small carbohydrate
2. A polypeptide composed of a repeated single amino acid
3. A phospholipid
4. A large complex protein
ability to initiate a new immune response on its own
antigen & immunogen
What two terms are often used interchangeably?
adjuvant can cause mild irritation that enhances ______________ processing
An immunogenic molecule can and often does have numerous unique antigenic determinants which are called _____________. They are characterized by their ability of an immunological component (cell or antibody) to bind to that specific region of the larger antigen molecule.
- polymers of a single peptide or poly saccharide unit
Epitopes may be found as _______________________________ or ________________ and are usually between 6 & 12 amino acids in length or 1-2 saccharide units
Large, non-polymeric macromolecular immunogens (40,000 Da) may express several non-identical _______________
T cells and B cells usually recognize _____________ types of epitopes
Which cells often recognize conformational or structural (related to secondary & tertiary structure) epitopes that are normally only found in intact/unprocessed molecules?
Which cells routinely recognize linear epitopes (related to primary structure or amino acid sequence only)
The parent antigen from which a T cell epitope is derive normally must be enzymatically broken down into smaller parts for epitopes to be recognized by T cells - a process called_________________
Sets with similar terms
Antigens and Antibodies
Immunology Lecture 1
453 Lecture 3 - Antigens
Ross Immunology: Antigens & Haptens
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Introduction into Immunology
cells of the immune system - general functions
Toll-like receptors - breakout session I
Antigen: Antibody reactions
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