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Anemia of Diminished Erythropoiesis

Terms in this set (89)

Describe a scenario in which dilutional anemia develops
Pt has acute blood loss (e.g. gunshot or car accident) and receives ONLY fluids to replace volume loss
What is the most frequent cause of chronic blood loss resulting in anemia?
GI bleed
How does the body hematopoietically respond to acute blood loss?
1. Increased EPO
2. Neutrophils released --> leukocytosis
3 causes of microcytic/hypochromic anemia
- Fe defiency
- Anemia of chronic disease
- Thalassemia
- Sideroblastic anemia (Pathoma only)
What 2 anemias are classified as megaloblastic?
- folate deficiency
- B12 deficiency
What is a cause of macrocytic/hyperchromic anemia that is non-megaloblastic?
liver disease
Hypoproliferative reticulocyte count indicates an anemia due to ____________
decreased production
Hyperproliferative reticulocyte count indicates an anemia due to _____________
increased destruction
What are some Signs and Symptoms of anemia?
- weakness
- pallor
- dyspnea
- headache (classically a band distribution)
- palpitations
- tachycardia
What form of anemia is associated with cerebellar problems?
B12 deficiency
B12 and folate both assist in the synthesis of what nucleotide for DNA?
thymidine
What occurs in "meagaloblastic maturation"?
DNA synthesis lags behind cytoplasmic maturation
Hypersegmented neutrophils (> 5 lobes) are associated with which form of anemia?
megaloblastic

-- due to either folate or B12 deficiency
Source of intrinsic factor
parietal cells in the body of the stomach
What salivary proteins bind to dietary B12?
R-binders
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