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Molecular Bio Exam 1 - DNA, RNA and the Flow of Genetic Information
Terms in this set (58)
Sugars are linked by _______
_______ on sugars carry genetic information
Four nucleosides in DNA are:
Deoxyadenosine, deoxyguanosine, deoxycytidine, and thymidine.
Four nucleoside in RNA are:
Adenosine, guanosine, cytidine, and uridine
A __________ is a base joined to a sugar by an __________ linkage
N-9 of a purine or N-1 of a pyrimidine is attached to C-1′ of the sugar by an ____________
A(n) _______________ is formed when both carbons have the same stereochemistry, whereas a(n) _______________occurs when the two carbons have different stereochemistry.
A nucleotide is a nucleoside joined to one or more ___________ by an ______ linkage
Four nucleotide in DNA are:
Deoxyadenylate, deoxyguanylate (Purines)
Deoxycytidylate, and thymidylate (Pyrimidines)
Four nucleotides in RNA are:
Adenylate, guanylate (purines)
Cytidylate and uridylate (Pyrimidines)
A ________ is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.
Sugars in both nucleic acids are linked to one another by ___________
In the linkage of sugars on both nucleic acids, specifically, the_______ group of the sugar moiety of one nucleotide is esterified to a __________, which is, in turn, joined to the ________ of the adjacent sugar.
___________ charge on phosphodiester bridge opposes hydrolytic attack by nucleophilic species.
Absence of -OH on 2`carbon of the deoxyribose sugar improves its resistance to ________.
_______ is constant in a nucleic acid while _______ vary from one monomer to the next.
By convention, the base sequence is written in the ________ direction.
Thus, ACG indicates that the unlinked 5′-OH group is on ___________, whereas the unlinked 3′-OH group is on _____________.
A = T
G = C
In the Watson-Crick model of DNA (B-form), two helical polynucleotide strands are coiled around a common axis with a _____-handed screw sense.
Watson-Crick model of DNA (B-form), the sugar-phosphate backbones are on the ______ of the helix
Watson-Crick model of DNA (B-form), the purine and pyrimidine bases lie on the ________ of the helix.
Watson-Crick model of DNA (B-form), the ______ are nearly perpendicular to the helix axis
Watson-Crick model of DNA (B-form), adjacent bases are separated by approximately _____Å
Watson-Crick model of DNA (B-form), the helical structure repeats on the order of every_____ Å, with about______ bases per turn of helix.
Watson-Crick model of DNA (B-form), there is a rotation of nearly ____ degrees per base
(360 degrees per full turn/10.4 bases per turn).
Watson-Crick model of DNA (B-form), the diameter of the helix is about ____Å
What contributes to the stability of the double helix?
The stacking of base pairs .
The formation of the double helix is facilitated by the _________ effect.
The stacked base pairs attract one another through ___________
van der Waals forces.
Major groove width:
Minor groove width:
___________spirals around the outer surface of the DNA.
_____________ groove has sequence-specific DNA binding proteins (transcription factors) interact with DNA
__________ groove has fluorescent dies (Hoechst 33258, DAPI) interact with DNA
A-DNA is a ______-handed double helix
Z-DNA is _______-handed double helix
In ____form DNA, its base pairs are tilted rather than perpendicular to the helix axis.
______ form DNA has a wider and shorter helix structure; broadest
In _______ form DNA, phosphoryl groups in the backbone are zigzagged
_____-DNA is the narrowest
Syn and anti refers to the orientation of the __________ between the _______ and_______
base and deoxyribose
Glycosidic bond in A-DNA is ______
Glycosidic bond in B-DNA is ______
Glycosidic bond in Z-DNA is ______
alternating anti and syn
Base pairs per turn of helix:
Rise per base pair:
The DNA in bacteria and archaea are ______
The DNA in human chromosomes are ______
Supercoiling is biologically important for two reasons:
1. A supercoiled DNA molecule is more compact.
2. Supercoiling may hinder or favor the capacity of the double helix to unwind and thereby affect the interactions between DNA and other molecules.
___________ nucleic acids often fold back on themselves to form well- defined simple stem-loop or complex structures.
Type of RNA that conveys genetic information to the ribosomes is _______
Type of RNA that deliver amino acids to ribosomes is _________
Type of RNA that links amino acids to form proteins is __________
If a substituent attached to the 1′-carbon of the deoxyribose sugar lies on the same face of the sugar ring as the 5′-hydroxyl group, it is known as the _____-anomer
If a substituent attached to the 1′-carbon of the deoxyribose sugar lies on the opposite face of the sugar ring as the 5′-hydroxyl group, it is known as the _____-anomer
All of the nucleosides in DNA are in the ____-configuration
Rotation about the N-glycosidic bond is restricted and the _____ conformation is generally favored, partly on steric grounds.
THIS SET IS OFTEN IN FOLDERS WITH...
Molecular Bio Exam 2- Translation
Molecular Bio Exam 2- Regulation of Gene Expression
Molecular Bio Exam 2- Recombinant DNA TOOLS
Molecular Bio Exam 2- Recombinant DNA Applications
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