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Pharmacology Lecture 1

Terms in this set (57)

absorption
movement of a drug from the site of administration into the bloodstream
factors that influence absorption
1. dose
2. route
3. blood flow
4. GI function
5. presence of food or other drugs
distribution
movement of drugs throughout the body
factors that influence distribution
blood flow
ability of drug to exit vascular system
ability of drug to enter cells
metabolism - where does it take place
Liver
first pass effect
oral drugs extensively metabolized by liver, leaves only small amount of drug to reach systemic circulation
Issues with metabolism in the liver
inactivation of the drug
toxicity
excretion
removal of drugs from the body occurs in the Kidneys
how are drugs excreted?
urine
bile
sweat
saliva
breast milk
expired air
serum drug levels
lab measurement of the amount of drug in the blood at a particular time
Minimum effective concentration (MEC)
1. Plasma drug level below with therapeutic effects will not occur
2. Therapeutic range lies between MEC and toxic concentration
Half life
time required for the serum concentration to decrease by 1/2
determines dosing intervals
agonist
turns on the receptor
antagonist
blocks or prevents activation of the receptor
drug-drug interaction
occurs when 2 or more drugs are taken together
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