Upgrade to remove ads
Terms in this set (54)
Term for undescended testis
Most common location for an undescended testis
2 complications of cryptorchidism
- infertility (due to temperature)
- 3x-5x higher risk for testicular cancer
Recommended treatment for cryptorchidism in a child 6-12 months old
surgical repositioning (orchiopexy)
Cryptorchid testes have a higher proportion of which cell type?
-- absent spermatogenesis but still produce testosterone
histological appearance of cryptorchid testes
thickened hyaline basement membranes
(FA) what increases the risk of cryptorchidism?
(FA) what happens to inhibin, LH, FSH levels in cryptorchidism?
LH & FSH inc
Orchitis and epididymitis in children is usually associated with ____ and the bacteria are usually:
congenital anomalies; gram negative rods
Orchitis and epididymitis in young males is most often _____ and the bacteria are usually: (2)
sexually transmitted; C. trachomatis or N. gonorrhoeae
Orchitis and epididymitis in older males is most commonly due to what 2 microbes?
- E coli
-- usually in the setting of BPH
Granulomatous orchitis is thought to be ____-mediated
When is testicular involvement of the mumps virus most common? Why is this significant?
post-pubertal males; bilateral involvement can cause infertility
Tuberculosis of the male genital tract invariably begins in the _____
Why portion of the male genital tract is first involved by syphilis?
Twisting of the spermatic cord that obstructs venous drainage while arterial flow is maintained
What should be done to the CL testis when a Pt experiences torsion?
orchiopexy; Pt likely had predisposition for first occurrence so this is a preventive measure
Most common tumors of men between the ages of 15 and 34
testicular germ cell tumors
All germ cell tumors are associated with what chromosomal abnormality?
isochromosome of 12p (short arm)
First site of metastasis for testicular cancer
retroperitoneal para-aortic lymph nodes
Classification of testicular cancer that is extremely radiosensitive and spreads late
Classification of testicular cancer that is radio-resistant and spreads early
note: now has 90% cure rate with combination chemotherapy
In-situ lesion of the testes thought to give rise to most germ cell tumors
intratubular germ cell neoplasia (ITGCN)
Most common pure germ cell tumor and its peak incidence
seminoma; 4th decade (never in infancy)
3 tumor markers associated with seminomas
1. placental alkaline phosphatase (ALP)
2. c-KIT (CD117)
Testicular tumor associated with interspersed reactive T-cell lymphocytes
(gross: homogenous, tan-gray, bulging)
(FA) histological appearance of seminoma
large cells with lobules in watery cytoplasm & "fried egg" appearance
Testicular tumor in older males (>65) with an admixture of 3 cell populations that does not metastasize
Testicular tumor sometimes described as having an "epithelioid" appearance
(gross: hemorrhage & necrosis, painful)
Testicular tumor with highly atypical nuclei with basophilic cytoplasm
Tumor markers associated with embryonal carcinoma
CD30 and Cytokeratin
Most common testicular tumor in infants and children (< 3 y.o.)
yolk sac tumor
Testicular tumor associated with Schiller-Duval bodies & reticular histological pattern
yolk sac tumor
Testicular tumor associated with elevated AFP
yolk sac tumor
note: A1AT may also be present
Embryological substitute for albumin
alpha-fetoprotein (also seen in liver HCC cancer)
-- elevated in yolk sac tumors
Blood vessel surrounded by tumor cell seen in a testicular tumor
-- associated with yolk sac tumors
Testicular tumor with early metastasis and poor prognosis
Testicular tumor composed for syncytiotrophoblasts and cytotrophoblasts
What cells produced HCG?
-- malignant in choriocarcinoma
Testicular tumor associated with tissue from various germ layers
Tissue type most commonly found in immature teratomas
What is the most common frank malignancy to arise from a teratoma?
squamous cell carcinoma
-- due to malignant transformation
Testicular tumor that presents with sexual precocity in children or gynecomastia in adults
Leydig cell tumor
Testicular tumor associated with crystalloids of Reinke
Leydig cell tumor
(FA) gross: golden brown
what are crystalloids of Reinke?
eosinophilic cytoplasmic inclusions in Leydig cells
Testicular tumor that forms structures reminiscent of immature seminiferous tubules
sertoli cell tumor (aka androblastoma)
Most common testicular tumor in males over 60
Most common type of lymphoma to present as a testicular mass
diffuse large B-cell lymphoma
Most common lesion of the proximal spermatic cord
-- retroperitoneal adipose tissue (normal, not neoplastic)
Cord lipomas are usually associated with what condition?
Most common benign paratesticular tumor
-- usually adjacent to the epididymis
Most common malignant paratesticular tumor in adults
Most common malignant paratesticular tumor in children
Paratesticular tumor that stains calretinin positive
-- benign mesothelial neoplasm (calretinin = mesothelial stain)
YOU MIGHT ALSO LIKE...
Reproductive Ovarian + Testicular Cancer
Gynecology and Testicular Disorders
G Path random
OTHER SETS BY THIS CREATOR
Aquifer Peds Midterm
Empiric Antimicrobials for Common Infectious Disea…
PDCI: Pediatric Eye Exam