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Terms in this set (31)
How many liters does the kidney filter?
What percentage of the filtrate is reabsorbed in the proximal tubule?
What gets handled by the proximal tubule?
1. Sodium Reabsorption
2. Chloride Reabsorption
3. Bicarbonate Reclamation/Acid Secretion
4. Glucose Reabsorption
5. Amino Acid Reabsorption
6. Phosphate Reabsoprtion
7. Weak organic Acid and Base Reabsorption and Polar Substances
Where is the basolateral side located?
On the side of the peri-tubular capillary
What is the primary solute that drives the reabsorption of most other solutes?
What percentage of glucose is reabsorbed in the proximal tubule via the SGLT 2?
What percentage of the filtered glucose is reabsorbed in the proximal tubule?
Endogenous Cations: Creatinine
Endogenous Cations: Dopamine
Endogenous Cations: Epinephrine
Endogenous Cations: Thiamine
Endogenous Anions: Bile Salts
Endogenous Anions: Fatty Acids
Endogenous Anions: Oxalate
Endogenous Anions: Prostaglandins
What is percentage of water reabsorbed in the thick ascending limb?
What percentage of filtered load of sodium is reabsorbed in the thick ascending limb?
What percentage of calcium and magnesium is reabsorbed in the thick ascending limb (critical site)
What percentage of filtered bicarbonate is reabsorbed in the thick ascending limb?
Clinical Effects of Furosemide
1. less sodium reabsorption leading to increased sodium (and water) excretion (volume depletion)
2. Potassium loss (hypokalemia)
3. Decreased Calcium reabsorption (increased calcium in urine)
4. Potential increased calcium based kidney stones
5. Increased Uric Acid in the urine with potential increased gout (although more common with NCC blockade)
What percentage of filtered sodium is reabsorbed in the distal convoluted tubule in the absence of water?
What is the primary transporter?
Na-Cl symporter (NCC)
What percentage of Ca and Mg are reabsorbed in the distal convoluted tubule?
What does NCC (diuretic ) block?
Thiazides: Hydrochlorothiazide and Thiazide Like: Chlorthalidone and Indapamide
What are the clinical effects of NCC?
1. Sodium and water loss
2. Potassium loss
3. Weirdly, increased calcium reabsorption (don't ask, we aren't sure)
4. May have profound effects on serum sodium (hyponatremia) particularly in elderly women
5. May precipitate gout attacks
What percentage of sodium is reabsorbed via the ENaC in the collecting duct?
Variable, up to 5%
What percentage of water is reabsorbed via the AQp in the collecting duct?
variable- up to 20%
What percentage of Na is reabsorbed in the proximal tubule?
What percentage of Na is reabsorbed in the thin ascending limb?
What percentage of water is reabsorbed in the thick ascending limb?
What percentage of water is reabsorbed in the distal convoluted tubule?
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