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Primary Billiary Cholangitis
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Which bile ducts does PBC affect?
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Small intralobular bile ducts
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Terms in this set (9)
Which bile ducts does PBC affect?
Small intralobular bile ducts
Which antibody is most specific for PBC?
AMA (98% specific)
ANA also commonly positive
Which immunoglobulin tends to be raised in PBC?
IgM
Who gets PBC?
Middle aged women
95% women, most often 30-65 years old
Classic presentation of PBC?
Usually asymptomatic and diagnosed based on deranged LFTs
If symptomatic:
- Fatigue
- Pruritis
- Skin hyperpigmentation/dryness
- Xanthelasma/xanthomata
- Right upper quandrant discomfort
Can progress to chronic liver disease
- Jaundice, hepatomegaly, signs of portal hypertension (splenomegaly, ascites, varices)