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Primary Billiary Cholangitis

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Which bile ducts does PBC affect?

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Terms in this set (9)

Which bile ducts does PBC affect?

Small intralobular bile ducts

Which antibody is most specific for PBC?

AMA (98% specific)
ANA also commonly positive

Which immunoglobulin tends to be raised in PBC?

Middle aged women
95% women, most often 30-65 years old

Classic presentation of PBC?

Usually asymptomatic and diagnosed based on deranged LFTs

If symptomatic:
- Fatigue
- Pruritis
- Skin hyperpigmentation/dryness
- Xanthelasma/xanthomata
- Right upper quandrant discomfort

Can progress to chronic liver disease
- Jaundice, hepatomegaly, signs of portal hypertension (splenomegaly, ascites, varices)