These cards cover the material taught by the University of Michigan Medical School, 2013-14.
1. Know the phases of the cell cycle: G0, G1, S, G2, and M.
2. Know the major checkpoints in the cell-cycle control system.
3. Know the cellular conditions which influence the passage of mammalian cells through the G1 check-point and the G2 check-point.
4. Know the mechanisms involved in the regulation of cyclin-dependent protein kinase activity.
5. Understand the role of the varying stabilities of cyclins.
6. Understand the role of cyclins and CDKs in controlling the progression through the Start checkpoint, the G1 to S transition, and S phase.
7. Understand the function and regulation of CDK inhibitors (a.k.a. CKIs, tumor suppressors).
8. Understand the role of MPF in controlling the G2 to M transition.
9. Understand the regulatory function of SCF and APC/C in control of proteolysis.
10. Understand the role of p53 in DNA damage and apoptosis.
11. Have a general understanding of the relationship of defects in cell cycle regulators in the causes of cancer.