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identifies the entire process by which erythrocytes are produced in the bone marrow.
occurs in the medullary marrow over 5 days.
maturation results in reduction in cell volume, condensation of chromatin, decrease in N:C volume
Pronormoblast or Rubriblast
most primitive nucleus
1.5% in normal bone marrow
chromatin strands are dispersed
divides in 12hrs
Basophilic Normoblast, Prorubicyte
chromatin begins to condense
daughter cells of pronormoblasts
require20hrs to develop
1-5% in normal bone marrow
smaller moer condensed chromatin in nucleus, cytoplasm mixed with pink or blue
normal adults 5-30% of bone marrow
not seen in peripheral blood
Orthochromatic Normoblast or Meta Rubicyte
Metarubricyte matures in 48hrs into reticulocyte
degenerating nucleus with clumpled chromatin (pynotic)
nucleus is extruded
should only be found in newborns
Polychromatophilic erythrocyte or Reticulocyte
released from marrow into peripheral circulation 2-3 days
carries oxygen from the liungs to the tissues where it is exchanged for carbon dioxide