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Membrane carriers and channels
Terms in this set (26)
A carrier that transports two molecules in opposite directions
A carrier that transports two molecuels in the same direction
A carrier that transports one molecules down its concentration gradient
The movement of an electrical signal through neurons by the Na-K pump
A large channel that allows water through
Family of cation channels consisting of trimers of subunits with two transmembrane helices; one example is the epithelial Na-channel
Family of cation channels consisting of trimers of subunits with two transmembrane helices; gated by extracellular ATP
Binds to calcium channels that are regualted by cyclic nucleotides or by calcium binding to calmodulin
In K-channel KcsA, they replace the water shell of the K+ ion without an energy penalty, allowing it to pass through
C1C chloride channel
Dimers of subunits with 14-18 transmembrane helices & a central pore occupied by three Cl- ions. In the closed state, one of these ions is displaced by a glutamate which blocks the pore. Can act like a carrier by conformational changes that cause the ions to move through
Cyclic nucleotide-gated channel
Gated by cAMP which will bind to the channel and block its pore
Created by moving ions up their concentration gradient and the energy from that potential can be used move other ions
Epithelial sodium channel
An amiloride-sensitive channel
When the pore of a channel is blocked by something
Glutamate receptor channel
Na/K channels that are opened by glutamate binding
A third conformational state that some carriers have
A carrier S5/S6 protein that is the most well studied. Transports K across membrane.
Relevant in action potential. Voltage gated channels are opened by depolarization in the membrane.
Cna be used to measure the potential created by a channel
Phosphate-binding loop. One in each subunit of S5/S6 protiens and other proteins that have the same structure at the core.
Way to record the electrical potential generated by a channel. Can patch clamp on cell or off cell.
S4 voltage sensor
Positive residues in this domain of voltage-gated channel sense membrane potential and change conformation accordingly
S5 and S6 helix
Type of transmembrane helix common in channels. Evolved first and so, are in many channels of the S5/S6 family
Creates the specificity of a carrier or channel. Will only allow a certain type of molecule through.
Large family of Na/Ca channels with 6 transmembrane helices. Have a S5/S6 structure in the middle. Are sensitive to temperature of food in the toungue but are also activated by chemical like menthol and spices
Voltage gated channel
Opens and closes based on membrane potential.
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