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Requires a carrier to move the drug against a concentration gradient. Requires energy.
Most accurate test to determine renal function. Normal range = 85-135ml/min. Elderly/female may be lower.
Fillers & inert substances used in drug preparation to allow the drug to take on a particular size/shape and to enhance drug dissolution
Onset of action
The time it takes to reach the minimum effect concentration after a drug is administered.
Peak drug level
Highest plasma concentration of drug at a specific time. Indicates rate of absorption.
1st phase. Drug breaks down & is prepared for metabolism. Disintegration + dissolution.
Effect of a drug action that varies from a predicted drug response because of genetic factors or heredity influence.
The process of drug movement to achieve drug action. Absorption + distribution + metabolism + excretion.
A process by which cells carry a drug across their membrane by engulfing drug particles.
A psychologic benefit from a compound that may not have the chemical structure of a drug effect.
The time it takes the drug to disintegrate and dissolve to become available for the body to absorb it.
1) Kinase-linked receptors 2)Ligand-gated ion channels 3)G protein-coupled receptor systems 4)Nuclear receptors
Therapeutic index (TI)
Estimates the margin of safety of a drug through the use of a ratio that measures the effective dose & lethal dose.
A client asks why the oral dose of his pain medication is higher than the intravenous dose. The nurse explains that with the oral dose, some of the drug is absorbed from the GI tract and is metabolized by the liver to an inactive drug form. This reduces the amount of active drug and is called (the):
Hepatic first pass
A nurse is learning how to draw peak and trough levels of a medication. The nurse is aware that the trough level is the:
Lowest plasma concentration of a drug.
Isoproterenol (Isuprel) is an example of a medication that enhances the beta receptors in the body. Drugs that enhance a response are known as:
When providing a medication, if the nurse wanted to select the route that ensures greatest bioavailability, that route is:
A client's creatinine clearance level is 105 ml/minute. Based on this information, a nurse would anticipate that the dose of the drug would be:
A nurse is providing an oral medication for pain relief to a client. To attain the fastest pain relief, the nurse administers the medication so that it is most rapidly absorbed from the gastrointestinal (GI) tract. Which of the following has the fastest absorption?
The serum half-life (t1/2) of a drug is:
the time required after absorption for half of the drug to be eliminated
A nurse is administering a high dose of a medication in order to rapidly achieve a minimum effective concentration. This dose is known as the:
Because of hereditary influence, drug action may vary from a predicted drug response. This is known as:
Oral medication passes through several phases and processes in order to achieve a physiological response. What is the order?
Dissolution, Absorption, Distribution, Metabolism, Excretion
A client's serum protein and albumin levels are below normal values. For a drug that is highly protein-bound, there would be:
More free drug in circulation
A client is taking a drug that is moderately highly protein-bound. Several days later, the client takes a second drug that is 90% protein-bound. What happens to the first drug that is highly protein-bound?
The first drug is released from the protein and becomes more pharmacologically active.
A client is suffering from end-stage renal disease. Because of this condition, the nurse monitors drug levels to assess for:
Undesired effects are frequently associated with a client stopping a medication before completion of the full course. Physiologic effects, not related to the desired effect, that can be predicted or associated with the use of the drug are called:
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