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Pharm Test 2

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GI disorders

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Terms in this set (139)

peptic ulcer disease; GERD; constipation; diarrhea (caused by gastroenteritis or c. diff from a lot of antibiotic therapy); Nausea and vomiting (most common side effect) ; inflammatory bowel disease (autoimmune)

acid production in the stomach

gastric juice pH is about 2; mucus/bicarbonate layer neutralizes acid pH at cell surface to about 7-fialure to do so causes acid reflux

peptic ulcer disease

lesions or erosions in the stomach (gastric) or small intestine (duodenal) mucosa; risk factors include: H. pylori, FMH, use of NSAIDs, corticosteroids, platelet inhibitors (ASA or clopidogrel), blood group O, smoking, caffeine, and stress

secreted continuously by cells of GI mucosa; forms a barrier protecting underlying cells against acid and pepsin

stays in mucus layer where it serves to neutralize many hydrogen ions that penetrate the mucus; released by pancreas where it protects acid from stomach that gets to duodenum