Study sets, textbooks, questions
Upgrade to remove ads
From the second lecture of blood block. Oncogenesis is the main topic of this material. These flash cards will focus on the main concepts and some the specific mechanisms invoked in cell cycle dysregulation.
Terms in this set (15)
Explain the Neu mutation, which can cause breast cancer, in general terms
The Neu mutation arises from an oncogenic mutation to Her2 and results in the dimerization of the Her2 tyrosine kinase enzyme-linked receptor. This mutation can cause breast cancer.
These two transcription factors are frequently overexpressed early on in oncogenesis in many cancers.
c-Fos and c-Myc
What protein is considered "the guardian of the genome"? What type of protein is it?
p53. It's a tumor suppressor transcription factor
Explain why the DNA of cancer cells sometimes have longer telomeres than normal cells.
bc longer telomeres will keep cancer cells in the cell cycle longer
How do slow tumor forming retroviruses cause cancer?
by introducing promoters and enhancer genes into the host cell's genome
This class of enzyme-coupled receptors is very important to cancer cell formation.
What are tumor suppressing genes?
Genes that encode proteins that prevent cell replication
Why do medications have to be adjusted and, in some cases changed, as cancer treatment progresses?
Bc as oncogenesis ensues driver and rider genes change identities and roles
What genes does the two hit origin of cancer theory not apply to?
oncogenes and proto-oncogenes
At what aminoacids in the primary sequence of Ras does mutation cause overexpression and thus cancer?
12 and 61
Outline the progression of neoplasm growth eventually reaching metastasis
Dysplasia (mild to severe, low to high grade); carcinoma in situ (metastasis possible, hasn't passed basement membrane); micro-invasive carcinoma (spread to basement membrane); frankly invasive carcinoma
What are the hallmarks of cancer?
Resistance to apoptosis; angiogenesis; telomerase overproduction; loss of tumor suppression; invasion and metastasis; oncogenic signaling; altered metabolism; genome instability and mutation; immune evasion; tumor promoted inflammation
What are fusion oncogenes?
when chromosomal translocation occurs two genes w/ related function may fuse together and enhance the shared effect of both proteins, leading to cell cycle disregulation.
What are more important for cancer prevention non-mutation of proto-oncogenes or tumor suppressor genes?
tumor suppressor genes
What is the function of the retinoblastoma protein
Sets with similar terms
Genetics and Molecular Biology Chapter 23: Cancer…
Genetics Chapter 18 - Genetics of Cancer
Human Genetics: Chapter 18
Other sets by this creator
Bleeding and coagulation disorders
Autonomic modulating drug examples
Cutaneous Fungal Infections
Other Quizlet sets