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39 terms

Midterm Test

STUDY
PLAY
path from genes to proteins
1. Transcription- enzymes use the base sequence of a gene to make a strand of RNA

2. Translation- Information in the RNA strand id decoded (translated) into a sequence of amino acids

3. Central Dogma of DNA to RNA to Protein
Central Dogma of DNA to RNA
1. Replication: DNA is replicated and passes on coded information
2. Transcription: Coded information is passed on to the RNA during transcription
3. Translation: Messenger RNA carries coded information to the ribosome during protein synthesis
4. Proteins provide structure and carry out almost all biological activity
Messenger RNA
Carries protein-building codes from DNA to ribosomes
Ribosomal DNA
(most abundant RNA in the cell)- Forms ribosomes where polypeptide chains are assembled
Transfer RNA
Delivers amino acids to ribsomes
RNA (structure and function)
sugar: Ribose
Bases: adenin-guanine/cytosine-uracil
Form: Single stranded
Function: disposable copies of heritable information
DNA (structure and function)
Sugars: deoxyribose
bases: adenine-guanine/cytosine-thynine
Form: Double-stranded helix
Function:Permanent storage of heritable information
Codon
Reading unit for translation machinery during translation
-starting codon is always AUG
-codons specify different amino acids
The Genetic Code
1. Messenger RNA carries DNA protein-building structures to ribosomes
2. Messenger RNA's messgae is written in codons
Three Stages of translation
1. initiation
2. Elongation
3. Termination
Mutations
_Mutations are permanent, small-scale changes in the base sequence of a gene

-Common mutations include insertions, delitions, and base-pair substitutions
Mitosis
(makes exact copies)- the basis of growth, cell replacement, and tissue repair in multicelled organisms
-the basis of asexual reproduction in single-celled and multicelled species
Meiosis
(Only in the context of sexual reproduction)
basis of sexual reproduction
reduces chromosome number by half to produce egg and sperm
Eukaryotic chromosomes
-association of DNA, histones, and other proteins
-proteins structurally organize the chromosome and affect access to its genes
Cell Cycle
1. New cell forms
2. Runs through Interphase
3. Ends when cell reproduces by nuclear and cytoplasmic division
Interphase
1. cell grows in mass and all cytoplasmic material is duplicated
2. DNA replication duplicates chromosomes
3. The cell prepares for division
Process of Mitosis
(a nuclear division method that maintains the chromosome number)
1. Prophase
2. Metaphase
3. Anaphase
4. Telophase
Prophase
1. duplicated chromosomes condense and prepare to form chromosomes
2. microtubules form a bipolar spindle
3.Nuclear envelope breaks down
Metaphase
1. Microtubules from one spindle pole harness one chromatid of each chromosome
2. microtubules from opposite poles then harness the sister chromatid
3. chromosomes are lined up in the middle of the cell
Anaphase
1. sister chromatids are detached from one another as the spindles move apart from each other
2. microtubules that overlap puch away from each other and spread the poles further apart
Telpophase
1. two identical clusters reach opposite poles
2. The nuclear envelope forms around each side
3. Both new nuclei have the parental chromosome number
Genes
sequences of DNA that encode heritable traits
Alleles
Slightly different forms of the same gene
Sexual Reproduction
-meiosis
-gamete formation
-fertilization
Meiosis
(nuclear division mechanism that precedes gamete formation in Eukaryotic cells and halves the parental chromosome number)
Fertilization
forms zygote (first cell of new individual)
Restores parental chromosome number
Meiosis I
-the first nuclear division
-each duplicated chromosome lines up with its homologous partner
-the two homologous chromosomes move apart, toward opposite spindle poles
Meiosis II
-The second nuclear division
- Sister chromatids are pulled away from each other
- Each is now an individual chromosome
prophase I
The first phase of meiosis I. During prophase I the replicated chromosomes condense, homologous chromsomes pair up, crossing over occurs between homologous chromosomes, the spindle is formed, and the nuclear envelope breaks apart into vesicles. Prophase I is the longest phase of meiosis.
Metaphase I
The second phase of meiosis I. During metaphase I the paired homologous chromsomes (tetrads) align at the center of the cell (the metaphase plate).
Anaphase I
The third phase of meiosis I. the replicated homologous chromosomes are separated (the tetrad is split) and pulled to opposite sides of the cell.
Telophase I
The fourth of meiosis I. the number of chromosoms is now reduced by half. After this phase the cell is considered to be haploid. Note however, that the chromosomes are still replicated, and the sister chromatids must still be separated during meiosis II.
Prophase II
The first phase of meiosis II. identical to the mitotic step, except that the number of chromosomes was reduced by half during meiosis I.
Metaphase II
The second phase of meiosis II. identical to the mitotic step, except that the number of chromosomes was reduced by half during meiosis I.
Anaphase II
- sister chromatids are pulled to opposite poles by the spindle fibers
Telophase II
4 cell results....each cell is haploid with unreplicated chromosomes
Variation during Meiosis
1. Crossing over during prophase 1
2. Chromosome shuffling during metaphase 1
3. Chance meeting of gametes at fertilization
Origin of Species Book was Published in....
1859
Evidence of Evolution
The fossil Record
Genetics
Geological time scale