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What causes hypothyroidism?
1)Primary: failure of thyroid to produce thyroid hormone
2)Secondary: failure of anterior pituitary to secrete TSH
3)Tertiary: failure of hypothalamus to produce TRH
Whats the formula for Free t4 index?
Free T4 index = (total serum T4 in mg/dL)*(T3 resin uptake in %)
How is free t4 index used?
indicator of thyroid status in presence of abnormalities in plasma protein binding
In primary hypothyrodism TSH before TRH stim ___, TSH after TRH stim ___
increase, exaggerated TSH response
In secondary hypothyrodism TSH before TRH stim ___, TSH after TRH stim ___
decrease, no tsh response
In tertiary hypothyrodism TSH before TRH stim ___, TSH after TRH stim ___
decrease, sluggish tsh response
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