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biomaterials quiz 2

Terms in this set (20)

migration is generally considered as a continual movement ____
cycle of lamellipod extension and cell body translocation
mechanical forces needed for locomotion are generally believed to be generated through
polymer filaments of the protein actin
what is the effect of material on host tissues
blood-material interactions, toxicity, modification of healing, inflammation, infection, tumorigenesis
what is the effect of environment on materials
wear, fatigue, corrosion, stress-corrosion cracking, adsorption of tissue constituents, ezymatic degradation, calcification
what are device associated problems
thrombosis, infection, defective healing, biomaterials failure, adverse local tissue reaction
white blood cells
leukocytes
phagocytose foreign invaders
granulocytes
move ino injury site 5-6 hours after inflammatory response begins, mature into macrophages, phagocytic capabilities
monocytes
t and b cells responsible for acquired immune system
lymphocytes/plasma cells
found in bone marrow and aid in blood clotting
megakaryocytes
leukocyte formation begins with
hematopoetic stem cells
type of granulocyte extravasate form the blood stream within an hour after injury in response to soluble factors in the inflamed tissue
neutrophils
non-degradable silica particles can cause increased macrophage death that leads to cytokine release that stimulates fibrous tissue formation
silicosis
particles too big for phagocytosis causes macrophages to surround the material and attempt to degrade it with lysosomal enzymes
frustrated phagocytosis
what are the effects of chemical mediators on inflammatory response
promote cell migration by increasing adhesion molecule expression on vascular endothelium, increased cam
what are the effects of chemical mediators on immune system
activate or promote migration of lymphocytes
what are the effects of chemical mediators on systemic stuff
cytokines induce acute-phase proteins by the liver which leads to an increased body temp, blood clotting cascade
attach and destroy parasites, detoxify inflammation, prevents spread of inflammation
eosinophils
activated to release heparin, hitamine, bradykin, serotonin, souluble mediators of inflammation, allergic systems, prevents blood from clotting too quickly, promotes blood flow to tissuesq
basophils
granulation tissue is formed by
proliferating fibroblasts and vascular endothelial cells
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