Most common malignant bone tumor
Breast, prostate, lung, thyroid, kidney
Usually multifocal; thyroid, kidney may be solitary
Pain, fracture, hypercalcemia, inc alk phos
Myelophthisis (marrow infiltration) characteristic peripheral blood changes
Spine, pelvis, ribs, skull, humerus, femur
Lytic (breast) or blastic (prostate), most are mixed
Usually results in osteolytic (punched out) lesion Widespread intraosseous proliferation of malignant plasma cells
Spine, ribs, pelvis, skull
Associated monoclonal gammopathy
Pain, lysis, fracture, inc calcium, anemia
Fever, weakness, weight loss, amyloid
Usually treated with bone marrow transplant
Solitary plasmacytoma: bone or viscera