Antidepressants and Mood Stabilizers

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classes of antidepressants

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Terms in this set (42)

-Tricyclic antidepressants (TCAs)
-Monoamine oxidase inhibitors (MAOIs)
-Selective serotonin reuptake inhibitors (SSRIs)
-Serotonin and norepinephrine reuptake inhibitors (SNRIs)
-Serotonin antagonist reuptake inhibitors (SARI's)

black box warning for antidepressants

-All antidepressants carry an FDA black box warning for increased risk of suicidality in children and adolescents

Why do antidepressants lead to increased suicidality?

-As antidepressants take effect and mood begins to lift, patient may have increased energy with which to carry out a suicide plan
-Suicide potential INCREASES as level of depression DECREASES
-Every patient on an antidepressant needs to be questioned about suicidal ideation

tricyclic antidepressants (TCAs) drugs

-Amitriptyline (Elavil)
-Amoxapine (Asendin)
-Clomipramine (Anafranil)
-Desipramine (Norpramin)
-Imipramine (Tofranil)
-Nortriptyline (Pamelor)
-Protriptyline (Vivactil)

characteristics of tricyclic antidepressants (TCAs)

-Most are Pregnancy Category C or D
-Metabolites can often cause problems with lingering side effects
-Now used at lower doses for neuropathic pain, bed wetting
-Lethality - 30 times average daily dose
-Anticholinergic side effects
-Orthostatic hypotension
-Sedation
-Diaphoresis
-Cardiac toxicity
-Seizures
-Hypomania