Neuropharmacology 1 structure and functions
Terms in this set (11)
what does too much glutamate cause?
Describe what is happening in Alzheimer's disease?
Brain tissue has fewer nerve cells and synapse;
Dead and dying nerve cells contain tangles, twisted strands off protein (tau) inside the cell.
Tau protects neurons. if it get's messed up, there is no repair.
Explain the process of neurodevelopment?***Imp
Neurogenesis - continues to 65
Neuronal Selection - Stops at birth
Migration from ventricular zone - stops at birth
Differentiation and myelination - continues to 65
Synaptogenesis - continues to 65
Brain restructuring (through competitive elimination)- Starts after birth
At which age do wee have a lot of synaptogenesis and pruning/competitive elimination?***IMP
Age 6 (synaptogenesis) and 14-60 (for pruning)
Name 2 places in adult brain where neurogenesis still happens?
Hippocampus and Olfactory bulb
what enhances neurogenesis in the hippocampus?
Learning, Exercise, Growth factor, and ANTIDEPRESANT
Stress, Aging, Deprssion
what is the critical element in Anti-depressant that allows the drug to enhance neurogenesis?***Imp
BDNF (brain derived neurotrophic factor
How does a person with high cholesterol affect neurogenesis and migration?**Imp
There is a recognition molecule known as *
*. Too much cholesterol will cause inhibition of APP metabolites which could lead to plaque in hippocampus, then inflammation and death of neurons
A patient with a Neurodevelopmental disorders means what?**IMP
failure to form proper connection
A patient with a Neurodegenerative disorders means what?**Imp
Loss of synapse
A patient with stroke should avoid what?
Glutamate toxicity, and enhance neuroplasticity