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Alterations in Hemostasis
Decrease in the number of circulating platelets. Usually caused by diseases of the bone marrow.
Idiopathic Thrombocytopenic Purpura
An autoimmune disorder that results in platelet antibody formation and the destruction of platelets.
X-linked recessive disorder. Primarily affects men. Low level of Factor VIII.
Von Willebrand Disease
Reduced platelet adhesion. Deficiency/defect of vW factor. Autosomal trait.
Disseminated Intravascular Coagulation
Widespread coagulation and bleeding in the vascular compartment.
Made in liver, kidney, smooth muscle, bone marrow.
Formed in bone marrow. Break apart to form many platelets.
Stored in spleen. Live 8-9 days in circulation. Released when needed.
plasma proteins- most syntesized by the liver.
von Willebrand factor
Coagulation factor made by endothelium.
vasoconstriction, formation of platelet plug, blood coagulation, clot retraction, clot dissolution