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Antidepressants - MOA/Tx/AE/D-Int
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Terms in this set (18)
TCA's - (MOA)
these drugs block the neuronal reuptake pump for norepinephrine and serotonin that removes monoamines from the synapse
TCA's - (Tx)
1. SECOND CHOICE - depression
2. bipolar disorder
3. fibromyalgia
4. insomnia
5. ADHD
TCA's - (AE)
1. anticholindergic effects (dry mouth, blurred vision, constipation, urinary retention)
2. sedation
3. orthostatic hypotension
4. seizures
5. cardiac toxicity (arrhythmias)
6. weight gain
7. sexual disfunction
8. mild mania, agitation
9. suicidality in children & adolesents
10. yawngasm - chlomipramine
SSRI's - (MOA)
these drugs selectively block the neuronal reuptake of serotonin into nerves
SSRI's - (Tx)
1. depression
2. bipolar disorder
3. obsessive compulsive disorder
4. panic disorder
5. bulimia
SSRI's - (AE)
1. anticholinergic effects - LOW
2. sedation
3. CNS stimulation (nervousness, insomnia, anxiety)
4. hypotension - NONE
5. seizures - LOW
6. cardiac toxicity - LITTLE or NONE
7. weight gain
8. sexual dysfunction (anorgasmia, decreased libido)
9. withdrawal syndrome
10. suicidality in children & adolescents
11. serotonin syndrome (agitation, confusion, incoordination, tremor)
SNRI's - (Tx)
effects similar to SSRI's, but NOT as well tolerated
SNRI's - (AE)
fewer adverse effects
1. constipation
2. CNS effects (nausea, fatigue, HA, insomnia, agitation)
3. sexual dysfunction
4. increased BP
5. withdrawal syndrome
6. suicidality in children & adolescents
7. serotonin syndrome
Bupropion - (Tx)
1. depression - well tolerated
2. quit smoking
Bupropion - (AE)
1. anticholinergic effects (dry mouth)
2. CNS effects (agitation, dizziness, insomnia, anorexia)
3. GI upset
4. seizures
(+) weight loss
(+) increased sexual desire
MAOI's - (MOA)
these drugs prevent the metabolism of norepinephrine and serotonin in nerve terminals
MAOI's - (Tx)
1. atypical depression
MAOI's - (AE)
1. CNS stimulation (anxiety, agitation, mania)
2. orthostatic hypotension
3. hypertensive crisis
(when used with drugs that increase norepinephrine or dietary tyramine)
St. John's Wort - (Tx)
1. mild depression
Lithium - (Tx)
1. MAIN TREATMENT - bipolar disorder
Lithium - (AE)
therapeutic plasma levels
1. teratogenesis
2. fine hand tremor
3. polyuria
4. transient - GI upset, fatigue, muscle weakness
excessive plasma levels
1. coarse tremor, confusion, sedation, incoordination
2. hypotension
3. seizures/coma
5. ECG changes
Lithium (D-Int)
1. low sodium levels
2. dehydration
3. NSAID's
Valproate (AE)
fewer AE than lithium, but somewhat less effective to control depression, bipolar relapse, and suicidal thoughts
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